TY - JOUR
T1 - Increased risk of herpes zoster in children with asthma
T2 - A population-based case-control study
AU - Kim, Bong Seong
AU - Mehra, Sonia
AU - Yawn, Barbara
AU - Grose, Charles
AU - Tarrell, Robert
AU - Lahr, Brian
AU - Juhn, Young J.
N1 - Funding Information:
Supported by the Clinician Scholarly Award from the Mayo Foundation , the Rochester Epidemiology Project ( R01 AG34676 from the National Institute on Aging ), and the UK National Immunization Council for data on childhood HZ and the National Institute of Allergy and Infectious Diseases ( R21 AI101277 to B.Y.). The authors declare no conflicts of interest.
PY - 2013/9
Y1 - 2013/9
N2 - Objective: To determine the risk of herpes zoster (HZ) in children with and without asthma. Study design: This study was designed as a population-based case-control study. We examined all children (aged <18 years) with possible HZ in Olmsted County, Minnesota, between 1996 and 2001 (n = 306; identified by International Classification of Diseases, Eighth Revision codes and predetermined criteria for HZ) to identify true cases. To determine the association between asthma and HZ, we compared the frequency of asthma among children with HZ with that among age- and sex-matched corresponding controls (1:1 matching) who resided in Olmsted County, Minnesota, during the study period. Asthma was ascertained based on predetermined criteria. A conditional logistic regression model was used to calculate ORs and 95% CIs. Results: We identified 277 eligible patients with HZ, 63 (23%) of whom had a history of asthma before the index date of HZ, compared with 35 of 277 (12.6%) matched controls (aOR, 2.09; 95% CI, 1.24-3.52; P =.006), adjusting for varicella vaccination and atopy status. The population-attributable risk percentage was 12%. Controlling for asthma and atopy status, varicella vaccination was associated with reduced risk of HZ (aOR, 0.44; 95% CI, 0.21-0.92; P =.028). Conclusion: Asthma may be an unrecognized risk factor for reactivation of a non-airway-related latent infection such as HZ in children.
AB - Objective: To determine the risk of herpes zoster (HZ) in children with and without asthma. Study design: This study was designed as a population-based case-control study. We examined all children (aged <18 years) with possible HZ in Olmsted County, Minnesota, between 1996 and 2001 (n = 306; identified by International Classification of Diseases, Eighth Revision codes and predetermined criteria for HZ) to identify true cases. To determine the association between asthma and HZ, we compared the frequency of asthma among children with HZ with that among age- and sex-matched corresponding controls (1:1 matching) who resided in Olmsted County, Minnesota, during the study period. Asthma was ascertained based on predetermined criteria. A conditional logistic regression model was used to calculate ORs and 95% CIs. Results: We identified 277 eligible patients with HZ, 63 (23%) of whom had a history of asthma before the index date of HZ, compared with 35 of 277 (12.6%) matched controls (aOR, 2.09; 95% CI, 1.24-3.52; P =.006), adjusting for varicella vaccination and atopy status. The population-attributable risk percentage was 12%. Controlling for asthma and atopy status, varicella vaccination was associated with reduced risk of HZ (aOR, 0.44; 95% CI, 0.21-0.92; P =.028). Conclusion: Asthma may be an unrecognized risk factor for reactivation of a non-airway-related latent infection such as HZ in children.
KW - HZ
KW - Herpes zoster
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U2 - 10.1016/j.jpeds.2013.03.010
DO - 10.1016/j.jpeds.2013.03.010
M3 - Article
C2 - 23587434
AN - SCOPUS:84882875653
SN - 0022-3476
VL - 163
SP - 816
EP - 821
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 3
ER -