Increased right ventricular afterload induces postsystolic thickening of the ventricular septum in nonischemic hearts

Stig Urheim, Theodore P. Abraham, Josef Korinek, Jian Wen Wang, Marek Belohlavek

Research output: Contribution to journalArticle

4 Scopus citations


Background: We aimed to assess whether myocardial postsystolic thickening (PST) can be induced by an acute increase in right ventricular (RV) afterload and, thus, demonstrate that PST may have a nonischemic cause. Methods: In 8 anesthetized open-chest pigs, radial strains of the interventricular septum (IVS) and left ventricular inferolateral wall were obtained by Doppler tissue echocardiography before and during constriction of the pulmonary artery. Results: After each constriction, RV peak systolic pressure increased from 30 ± 5 to 57 ± 8 mm Hg (P < .001). Peak systolic radial strain of the IVS decreased from 20.8% ± 5.3% to 9.5% ± 4.1% (P = .003), and PST of the IVS increased from 0.3% ± 0.5% to 6.1% ± 4.8% (P = .01). The onset of PST started 41 ± 20 milliseconds after peak negative dP/dt of RV pressure. The inferolateral wall did not show PST. Conclusion: An acute increase in RV pressure causes a significant reduction in peak systolic strain of the IVS associated with the nonischemic appearance of PST.

Original languageEnglish (US)
Pages (from-to)839-843
Number of pages5
JournalJournal of the American Society of Echocardiography
Issue number8
StatePublished - Aug 1 2005


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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