Background: We aimed to assess whether myocardial postsystolic thickening (PST) can be induced by an acute increase in right ventricular (RV) afterload and, thus, demonstrate that PST may have a nonischemic cause. Methods: In 8 anesthetized open-chest pigs, radial strains of the interventricular septum (IVS) and left ventricular inferolateral wall were obtained by Doppler tissue echocardiography before and during constriction of the pulmonary artery. Results: After each constriction, RV peak systolic pressure increased from 30 ± 5 to 57 ± 8 mm Hg (P < .001). Peak systolic radial strain of the IVS decreased from 20.8% ± 5.3% to 9.5% ± 4.1% (P = .003), and PST of the IVS increased from 0.3% ± 0.5% to 6.1% ± 4.8% (P = .01). The onset of PST started 41 ± 20 milliseconds after peak negative dP/dt of RV pressure. The inferolateral wall did not show PST. Conclusion: An acute increase in RV pressure causes a significant reduction in peak systolic strain of the IVS associated with the nonischemic appearance of PST.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of the American Society of Echocardiography|
|State||Published - Aug 1 2005|
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine