Increased prostatic blood flow in response to microwave thermal treatment: Preliminary findings in two patients with benign prostatic hyperplasia

Thayne R. Larson, Joseph M. Collins

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Abstract. Objectives: To determine the effects on prostate blood flow of heat generated by microwave thermal t reatment in patients with benign prostatic hyperplasia. Methods: Prostate blood flow was evaluated by continuous transrectal color Doppler ultrasonography in 2 patients at baseline, after implantation of interstitial needles used for thermal mapping, and during microwave thermal treatment. Temperatures at 30 prostatic, periprostatic, urethral, and rectal sites were continuously monitored. In 1 patient, transrectal prostate compression was applied and the blood flow and temperature response to this maneuver noted. Results: Microwave thermal treatment achieved maximum prostate temperatures of 59 °C at 5 mm radially from the urethra. Urethral and rectal temperatures remained low. Marked increases occurred in prostate blood flow in response to microwave thermal treatment. These increases were apparent throughout the prostate gland, with the greatest increase in perfusion occurring in the peripheral zone and the posterior half of the transitional zone. After 15 minutes of microwave treatment, peak systolic blood flow increased 99% and 70% in patients 1 and 2, respectively, while end-diastolic blood flow climbed 50% and 112%, respectively. Prostate compression resulted in a prompt quenching of blood flow and an increase in prostate temperature. Conclusions: Based on these preliminary findings in 2 patients, prostate blood flow increases markedly in response to microwave thermal treatment. This compensatory increase in blood flow is likely to be a significant treatment-limiting factor in achieving effective thermoablation.

Original languageEnglish (US)
Pages (from-to)584-590
Number of pages7
JournalUrology
Volume46
Issue number4
DOIs
StatePublished - 1995

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Prostatic Hyperplasia
Microwaves
Prostate
Hot Temperature
Temperature
Therapeutics
Doppler Color Ultrasonography
Urethra
Needles
Perfusion

ASJC Scopus subject areas

  • Urology

Cite this

Increased prostatic blood flow in response to microwave thermal treatment : Preliminary findings in two patients with benign prostatic hyperplasia. / Larson, Thayne R.; Collins, Joseph M.

In: Urology, Vol. 46, No. 4, 1995, p. 584-590.

Research output: Contribution to journalArticle

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