Increased prevalence of reduced estimated glomerular filtration rate in chronic Hepatitis C patients

Sorin A. Petre, Mankanwal S. Sachdev, Brie N. Noble, Marianne Rosati, Marek J. Mazur, Raymond L. Heilman, M. Edwyn Harrison, David D. Douglas, Vijayan Balan

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background To investigate the prevalence and severity of reduced estimated glomerular filtration rate (eGFR) in patients with chronic hepatitis C (CHC). Methods Medical record review of 831 consecutive CHC patients seen in our clinic between July 2000 and August 2003; eGFR was estimated using the abbreviated Modification of Diet in Renal Disease (aMDRD) equation. The stage of kidney disease was determined based on eGFR expressed in milliliters per minute per 1.73 m2: stage 1 (signs of kidney damage but normal or elevated (eGFR ≥90), stage 2 (eGFR 60-89), stage 3 (30-59), stage 4 (eGFR 15-29), stage 5 (eGFR<15 or dialysisdependent). Results A total of 522 patients had available data with using the aMDRD equation, 51% had abnormal eGFR (stage 1, 4.6%; stage 2, 36.4%; stage 3 or 4, 6.1%; stage 5, 3.8%). Of 190 patients with stage 2 kidney disease, 189 patients (99.5%) had normal serum creatinine and only one patient (0.5%) had elevated creatinine concentrations (<1.4 mg/dl). Of the 32 patients with stage 3 or 4 disease, 20 (62.5%) had a normal serum creatinine concentration. Of 349 patients without diseases known to cause renal insufficiency, 38% had stage 2-4 renal disease. In a subset of these patients, 95/522 (18%) the measured creatinine clearance showed good correlation with their aMDRD (R = 0.47, (p<0.0001). Conclusions In CHC patients, a normal serum creatinine concentration does not assure normal kidney function. Estimation of eGFR with the aMDRD equation is a more accurate method of identifying patients with chronic kidney disease and reduced eGFR. Therefore, CHC patients should be screened more rigorously for chronic kidney disease because of the high prevalence of reduced eGFR. Lastly, in all CHC patients, the aMDRD eGFR should beused in each encounter with these patients when assessing their renal function irrespective of their serum creatinine.

Original languageEnglish (US)
Pages (from-to)1450-1457
Number of pages8
JournalDigestive Diseases and Sciences
Volume55
Issue number5
DOIs
StatePublished - May 2010

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Chronic Hepatitis C
Glomerular Filtration Rate
Diet Therapy
Kidney
Creatinine
Kidney Diseases
Serum
Chronic Renal Insufficiency
Medical Records
Renal Insufficiency

Keywords

  • Chronic kidney disease
  • Hepatitis C
  • Screening methods

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

Petre, S. A., Sachdev, M. S., Noble, B. N., Rosati, M., Mazur, M. J., Heilman, R. L., ... Balan, V. (2010). Increased prevalence of reduced estimated glomerular filtration rate in chronic Hepatitis C patients. Digestive Diseases and Sciences, 55(5), 1450-1457. https://doi.org/10.1007/s10620-010-1170-0

Increased prevalence of reduced estimated glomerular filtration rate in chronic Hepatitis C patients. / Petre, Sorin A.; Sachdev, Mankanwal S.; Noble, Brie N.; Rosati, Marianne; Mazur, Marek J.; Heilman, Raymond L.; Harrison, M. Edwyn; Douglas, David D.; Balan, Vijayan.

In: Digestive Diseases and Sciences, Vol. 55, No. 5, 05.2010, p. 1450-1457.

Research output: Contribution to journalArticle

Petre, SA, Sachdev, MS, Noble, BN, Rosati, M, Mazur, MJ, Heilman, RL, Harrison, ME, Douglas, DD & Balan, V 2010, 'Increased prevalence of reduced estimated glomerular filtration rate in chronic Hepatitis C patients', Digestive Diseases and Sciences, vol. 55, no. 5, pp. 1450-1457. https://doi.org/10.1007/s10620-010-1170-0
Petre, Sorin A. ; Sachdev, Mankanwal S. ; Noble, Brie N. ; Rosati, Marianne ; Mazur, Marek J. ; Heilman, Raymond L. ; Harrison, M. Edwyn ; Douglas, David D. ; Balan, Vijayan. / Increased prevalence of reduced estimated glomerular filtration rate in chronic Hepatitis C patients. In: Digestive Diseases and Sciences. 2010 ; Vol. 55, No. 5. pp. 1450-1457.
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abstract = "Background To investigate the prevalence and severity of reduced estimated glomerular filtration rate (eGFR) in patients with chronic hepatitis C (CHC). Methods Medical record review of 831 consecutive CHC patients seen in our clinic between July 2000 and August 2003; eGFR was estimated using the abbreviated Modification of Diet in Renal Disease (aMDRD) equation. The stage of kidney disease was determined based on eGFR expressed in milliliters per minute per 1.73 m2: stage 1 (signs of kidney damage but normal or elevated (eGFR ≥90), stage 2 (eGFR 60-89), stage 3 (30-59), stage 4 (eGFR 15-29), stage 5 (eGFR<15 or dialysisdependent). Results A total of 522 patients had available data with using the aMDRD equation, 51{\%} had abnormal eGFR (stage 1, 4.6{\%}; stage 2, 36.4{\%}; stage 3 or 4, 6.1{\%}; stage 5, 3.8{\%}). Of 190 patients with stage 2 kidney disease, 189 patients (99.5{\%}) had normal serum creatinine and only one patient (0.5{\%}) had elevated creatinine concentrations (<1.4 mg/dl). Of the 32 patients with stage 3 or 4 disease, 20 (62.5{\%}) had a normal serum creatinine concentration. Of 349 patients without diseases known to cause renal insufficiency, 38{\%} had stage 2-4 renal disease. In a subset of these patients, 95/522 (18{\%}) the measured creatinine clearance showed good correlation with their aMDRD (R = 0.47, (p<0.0001). Conclusions In CHC patients, a normal serum creatinine concentration does not assure normal kidney function. Estimation of eGFR with the aMDRD equation is a more accurate method of identifying patients with chronic kidney disease and reduced eGFR. Therefore, CHC patients should be screened more rigorously for chronic kidney disease because of the high prevalence of reduced eGFR. Lastly, in all CHC patients, the aMDRD eGFR should beused in each encounter with these patients when assessing their renal function irrespective of their serum creatinine.",
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AU - Sachdev, Mankanwal S.

AU - Noble, Brie N.

AU - Rosati, Marianne

AU - Mazur, Marek J.

AU - Heilman, Raymond L.

AU - Harrison, M. Edwyn

AU - Douglas, David D.

AU - Balan, Vijayan

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N2 - Background To investigate the prevalence and severity of reduced estimated glomerular filtration rate (eGFR) in patients with chronic hepatitis C (CHC). Methods Medical record review of 831 consecutive CHC patients seen in our clinic between July 2000 and August 2003; eGFR was estimated using the abbreviated Modification of Diet in Renal Disease (aMDRD) equation. The stage of kidney disease was determined based on eGFR expressed in milliliters per minute per 1.73 m2: stage 1 (signs of kidney damage but normal or elevated (eGFR ≥90), stage 2 (eGFR 60-89), stage 3 (30-59), stage 4 (eGFR 15-29), stage 5 (eGFR<15 or dialysisdependent). Results A total of 522 patients had available data with using the aMDRD equation, 51% had abnormal eGFR (stage 1, 4.6%; stage 2, 36.4%; stage 3 or 4, 6.1%; stage 5, 3.8%). Of 190 patients with stage 2 kidney disease, 189 patients (99.5%) had normal serum creatinine and only one patient (0.5%) had elevated creatinine concentrations (<1.4 mg/dl). Of the 32 patients with stage 3 or 4 disease, 20 (62.5%) had a normal serum creatinine concentration. Of 349 patients without diseases known to cause renal insufficiency, 38% had stage 2-4 renal disease. In a subset of these patients, 95/522 (18%) the measured creatinine clearance showed good correlation with their aMDRD (R = 0.47, (p<0.0001). Conclusions In CHC patients, a normal serum creatinine concentration does not assure normal kidney function. Estimation of eGFR with the aMDRD equation is a more accurate method of identifying patients with chronic kidney disease and reduced eGFR. Therefore, CHC patients should be screened more rigorously for chronic kidney disease because of the high prevalence of reduced eGFR. Lastly, in all CHC patients, the aMDRD eGFR should beused in each encounter with these patients when assessing their renal function irrespective of their serum creatinine.

AB - Background To investigate the prevalence and severity of reduced estimated glomerular filtration rate (eGFR) in patients with chronic hepatitis C (CHC). Methods Medical record review of 831 consecutive CHC patients seen in our clinic between July 2000 and August 2003; eGFR was estimated using the abbreviated Modification of Diet in Renal Disease (aMDRD) equation. The stage of kidney disease was determined based on eGFR expressed in milliliters per minute per 1.73 m2: stage 1 (signs of kidney damage but normal or elevated (eGFR ≥90), stage 2 (eGFR 60-89), stage 3 (30-59), stage 4 (eGFR 15-29), stage 5 (eGFR<15 or dialysisdependent). Results A total of 522 patients had available data with using the aMDRD equation, 51% had abnormal eGFR (stage 1, 4.6%; stage 2, 36.4%; stage 3 or 4, 6.1%; stage 5, 3.8%). Of 190 patients with stage 2 kidney disease, 189 patients (99.5%) had normal serum creatinine and only one patient (0.5%) had elevated creatinine concentrations (<1.4 mg/dl). Of the 32 patients with stage 3 or 4 disease, 20 (62.5%) had a normal serum creatinine concentration. Of 349 patients without diseases known to cause renal insufficiency, 38% had stage 2-4 renal disease. In a subset of these patients, 95/522 (18%) the measured creatinine clearance showed good correlation with their aMDRD (R = 0.47, (p<0.0001). Conclusions In CHC patients, a normal serum creatinine concentration does not assure normal kidney function. Estimation of eGFR with the aMDRD equation is a more accurate method of identifying patients with chronic kidney disease and reduced eGFR. Therefore, CHC patients should be screened more rigorously for chronic kidney disease because of the high prevalence of reduced eGFR. Lastly, in all CHC patients, the aMDRD eGFR should beused in each encounter with these patients when assessing their renal function irrespective of their serum creatinine.

KW - Chronic kidney disease

KW - Hepatitis C

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