Increased prevalence of light chain monoclonal gammopathy of undetermined significance (LC-MGUS) in first-degree relatives of individuals with multiple myeloma

Alexandra J. Greenberg; S. Vincent Rajkumar; Dirk R. Larson; Angela Dispenzieri; Terry M. Therneau; Colin L. Colby; Tara K. Phelps; Shaji K. Kumar; Jerry A. Katzmann; Robert A. Kyle; Susan L. Slager; Celine M. Vachon

doi:10.1111/j.1365-2141.2012.09075.x

Increased prevalence of light chain monoclonal gammopathy of undetermined significance (LC-MGUS) in first-degree relatives of individuals with multiple myeloma

Alexandra J. Greenberg, S. Vincent Rajkumar, Dirk R. Larson, Angela Dispenzieri, Terry M. Therneau, Colin L. Colby, Tara K. Phelps, Shaji K. Kumar, Jerry A. Katzmann, Robert A. Kyle, Susan L. Slager, Celine M. Vachon

Research output: Contribution to journal › Article › peer-review

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Abstract

Previously, we reported increased risk of heavy-chain (HC) monoclonal gammopathy of undetermined significance (MGUS) among first-degree (1°) relatives of multiple myeloma (MM) or HC-MGUS probands. This study investigated whether there was comparable risk for light-chain (LC) MGUS among 911 relatives of the same HC-MGUS/MM probands versus a reference population of 21 463. Seventeen 1° relatives had LC-MGUS (adjusted prevalence = 1·7%, 95% CI = 0·9-2·6%). There was increased risk of LC-MGUS in relatives of MM probands (RR = 3·4, 95% CI = 2·0-5·5). We saw no increased risk in relatives of HC-MGUS probands. We conclude that the prevalence of LC-MGUS is significantly higher among 1° relatives of MM probands compared to the reference population.

Original language	English (US)
Pages (from-to)	472-475
Number of pages	4
Journal	British journal of haematology
Volume	157
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2141.2012.09075.x
State	Published - May 2012

Keywords

Epidemiology
MGUS
Myeloma

ASJC Scopus subject areas

Hematology

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10.1111/j.1365-2141.2012.09075.x

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Greenberg, A. J., Vincent Rajkumar, S., Larson, D. R., Dispenzieri, A., Therneau, T. M., Colby, C. L., Phelps, T. K., Kumar, S. K., Katzmann, J. A., Kyle, R. A., Slager, S. L., & Vachon, C. M. (2012). Increased prevalence of light chain monoclonal gammopathy of undetermined significance (LC-MGUS) in first-degree relatives of individuals with multiple myeloma. British journal of haematology, 157(4), 472-475. https://doi.org/10.1111/j.1365-2141.2012.09075.x

Increased prevalence of light chain monoclonal gammopathy of undetermined significance (LC-MGUS) in first-degree relatives of individuals with multiple myeloma. / Greenberg, Alexandra J.; Vincent Rajkumar, S.; Larson, Dirk R. et al.
In: British journal of haematology, Vol. 157, No. 4, 05.2012, p. 472-475.

Research output: Contribution to journal › Article › peer-review

Greenberg, AJ, Vincent Rajkumar, S, Larson, DR, Dispenzieri, A , Therneau, TM, Colby, CL, Phelps, TK, Kumar, SK, Katzmann, JA, Kyle, RA, Slager, SL & Vachon, CM 2012, 'Increased prevalence of light chain monoclonal gammopathy of undetermined significance (LC-MGUS) in first-degree relatives of individuals with multiple myeloma', British journal of haematology, vol. 157, no. 4, pp. 472-475. https://doi.org/10.1111/j.1365-2141.2012.09075.x

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abstract = "Previously, we reported increased risk of heavy-chain (HC) monoclonal gammopathy of undetermined significance (MGUS) among first-degree (1°) relatives of multiple myeloma (MM) or HC-MGUS probands. This study investigated whether there was comparable risk for light-chain (LC) MGUS among 911 relatives of the same HC-MGUS/MM probands versus a reference population of 21 463. Seventeen 1° relatives had LC-MGUS (adjusted prevalence = 1·7%, 95% CI = 0·9-2·6%). There was increased risk of LC-MGUS in relatives of MM probands (RR = 3·4, 95% CI = 2·0-5·5). We saw no increased risk in relatives of HC-MGUS probands. We conclude that the prevalence of LC-MGUS is significantly higher among 1° relatives of MM probands compared to the reference population.",

keywords = "Epidemiology, MGUS, Myeloma",

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AU - Therneau, Terry M.

AU - Colby, Colin L.

AU - Phelps, Tara K.

AU - Kumar, Shaji K.

AU - Katzmann, Jerry A.

AU - Kyle, Robert A.

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AB - Previously, we reported increased risk of heavy-chain (HC) monoclonal gammopathy of undetermined significance (MGUS) among first-degree (1°) relatives of multiple myeloma (MM) or HC-MGUS probands. This study investigated whether there was comparable risk for light-chain (LC) MGUS among 911 relatives of the same HC-MGUS/MM probands versus a reference population of 21 463. Seventeen 1° relatives had LC-MGUS (adjusted prevalence = 1·7%, 95% CI = 0·9-2·6%). There was increased risk of LC-MGUS in relatives of MM probands (RR = 3·4, 95% CI = 2·0-5·5). We saw no increased risk in relatives of HC-MGUS probands. We conclude that the prevalence of LC-MGUS is significantly higher among 1° relatives of MM probands compared to the reference population.

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Increased prevalence of light chain monoclonal gammopathy of undetermined significance (LC-MGUS) in first-degree relatives of individuals with multiple myeloma

Abstract

Keywords

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