Increased prevalence of light chain monoclonal gammopathy of undetermined significance (LC-MGUS) in first-degree relatives of individuals with multiple myeloma

Alexandra J. Greenberg, S. Vincent Rajkumar, Dirk R. Larson, Angela Dispenzieri, Terry M. Therneau, Colin L. Colby, Tara K. Phelps, Shaji K. Kumar, Jerry A. Katzmann, Robert A. Kyle, Susan L. Slager, Celine M. Vachon

Research output: Contribution to journalArticle

10 Scopus citations


Previously, we reported increased risk of heavy-chain (HC) monoclonal gammopathy of undetermined significance (MGUS) among first-degree (1°) relatives of multiple myeloma (MM) or HC-MGUS probands. This study investigated whether there was comparable risk for light-chain (LC) MGUS among 911 relatives of the same HC-MGUS/MM probands versus a reference population of 21 463. Seventeen 1° relatives had LC-MGUS (adjusted prevalence = 1·7%, 95% CI = 0·9-2·6%). There was increased risk of LC-MGUS in relatives of MM probands (RR = 3·4, 95% CI = 2·0-5·5). We saw no increased risk in relatives of HC-MGUS probands. We conclude that the prevalence of LC-MGUS is significantly higher among 1° relatives of MM probands compared to the reference population.

Original languageEnglish (US)
Pages (from-to)472-475
Number of pages4
JournalBritish journal of haematology
Issue number4
StatePublished - May 1 2012



  • Epidemiology
  • MGUS
  • Myeloma

ASJC Scopus subject areas

  • Hematology

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