Increased potency and sustained suppressive actions of a new gonadotropin-releasing hormone (GnRH) antagonist peptide in man.

R. J. Urban, S. N. Pavlou, J. E. Rivier, W. W. Vale, M. L. Dufau, Johannes D Veldhuis

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2 Scopus citations

Abstract

We have used a new potent GnRH antagonist to assess the efficacy of suppression of gonadotropin secretion in healthy postmenopausal women at three different doses. The Nal-Glu antagonist produced significant suppression of immunoactive and bioactive LH at a 300 micrograms/kg dose throughout the 30-hr sampling interval with only minimal local (skin) histamine release. This increased potency and decreased skin reactivity of the Nal-Glu antagonist make it a drug with potential clinical use similar to the GnRH agonist, but with the advantage of immediate gonadotropin suppression.

Original languageEnglish (US)
Pages (from-to)302-309
Number of pages8
JournalTransactions of the Association of American Physicians
Volume101
StatePublished - 1988
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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