Increased phosphorylation rate of intermediate filaments during mitotic arrest

Sabina I. Robinson; Barry Nelkin; Scott Kaufmann; Bert Vogelstein

doi:10.1016/0014-4827(81)90338-4

Increased phosphorylation rate of intermediate filaments during mitotic arrest

Sabina I. Robinson, Barry Nelkin, Scott Kaufmann, Bert Vogelstein

Oncology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A detergent insoluble 58 000 D polypeptide is phosphorylated at an increased rate during mitotic arrest in cultured Chinese hamster ovary cells. Using one-dimensional peptide mapping, this polypeptide was identified as a phosphorylated form of intermediate filament protein (IFP). The increased rate of phosphorylation is observed with either colcemid- or vinblastine-treated mitotic cells, but is not seen with similarly treated interphase cells.

Original language	English (US)
Pages (from-to)	445-449
Number of pages	5
Journal	Experimental Cell Research
Volume	133
Issue number	2
DOIs	https://doi.org/10.1016/0014-4827(81)90338-4
State	Published - Jun 1981

ASJC Scopus subject areas

Cell Biology

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title = "Increased phosphorylation rate of intermediate filaments during mitotic arrest",

abstract = "A detergent insoluble 58 000 D polypeptide is phosphorylated at an increased rate during mitotic arrest in cultured Chinese hamster ovary cells. Using one-dimensional peptide mapping, this polypeptide was identified as a phosphorylated form of intermediate filament protein (IFP). The increased rate of phosphorylation is observed with either colcemid- or vinblastine-treated mitotic cells, but is not seen with similarly treated interphase cells.",

author = "Robinson, {Sabina I.} and Barry Nelkin and Scott Kaufmann and Bert Vogelstein",

year = "1981",

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AU - Kaufmann, Scott

AU - Vogelstein, Bert

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N2 - A detergent insoluble 58 000 D polypeptide is phosphorylated at an increased rate during mitotic arrest in cultured Chinese hamster ovary cells. Using one-dimensional peptide mapping, this polypeptide was identified as a phosphorylated form of intermediate filament protein (IFP). The increased rate of phosphorylation is observed with either colcemid- or vinblastine-treated mitotic cells, but is not seen with similarly treated interphase cells.

AB - A detergent insoluble 58 000 D polypeptide is phosphorylated at an increased rate during mitotic arrest in cultured Chinese hamster ovary cells. Using one-dimensional peptide mapping, this polypeptide was identified as a phosphorylated form of intermediate filament protein (IFP). The increased rate of phosphorylation is observed with either colcemid- or vinblastine-treated mitotic cells, but is not seen with similarly treated interphase cells.

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