Increased neural cell adhesion molecule in the CSF of patients with mood disorder

Maciej Poltorak, Mark A Frye, Renee Wright, John J. Hemperly, Mark S. George, Peggy J. Pazzaglia, Shari A. Jerrels, Robert M. Post, William J. Freed

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Neural cell adhesion molecule (N-CAM) is involved in cell-cell interactions during synaptogenesis, morphogenesis, and plasticity of the nervous system. Disturbances in synaptic restructuring and neural plasticity may be related to the pathogenesis of several neuropsychiatric diseases, including mood disorders and schizophrenia. Disturbances in brain cellular function may alter concentrations of N-CAM in the CSF. Soluble human N-CAM proteins are detectable in the CSF but are minor constituents of serum. We have recently found an increase in N-CAM content in the CSF of patients with schizophrenia. Although the pathogenesis of both schizophrenia and mood disorders is unknown, ventriculomegaly, decreased temporal lobe volume, and subcortical structural abnormalities have been reported for both disorders. We have therefore measured N-CAM concentrations in the CSF of patients with mood disorder. There were significant increases in amounts of N-CAM immunoreactive proteins, primarily the 120-kDa band, in the CSF of psychiatric inpatients with bipolar mood disorder type I and recurrent unipolar major depression. There were no differences in bipolar mood disorder type II patients as compared with normals. There were no significant effects of medication treatment on N-CAM concentrations. It is possible that the 120- kDa N-CAM band present in the CSF is derived from CNS cells as a secreted soluble N-CAM isoform. Our results suggest the possibility of latent state- related disturbances in N-CAM cellular function, i.e., residue from a previous episode, or abnormal N-CAM turnover in the CNS of patients with mood disorder.

Original languageEnglish (US)
Pages (from-to)1532-1538
Number of pages7
JournalJournal of Neurochemistry
Volume66
Issue number4
StatePublished - Apr 1996
Externally publishedYes

Fingerprint

Neural Cell Adhesion Molecules
Mood Disorders
Schizophrenia
Neuronal Plasticity
Bipolar Disorder
Plasticity
Neurology
Temporal Lobe
Depressive Disorder
Morphogenesis
Cell Communication
Nervous System
Psychiatry
Inpatients
Brain
Protein Isoforms
Proteins

Keywords

  • Bipolar mood disorder
  • Cell recognition molecule
  • Cerebrospinal fluid
  • Depression
  • Neural cell adhesion molecule

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Poltorak, M., Frye, M. A., Wright, R., Hemperly, J. J., George, M. S., Pazzaglia, P. J., ... Freed, W. J. (1996). Increased neural cell adhesion molecule in the CSF of patients with mood disorder. Journal of Neurochemistry, 66(4), 1532-1538.

Increased neural cell adhesion molecule in the CSF of patients with mood disorder. / Poltorak, Maciej; Frye, Mark A; Wright, Renee; Hemperly, John J.; George, Mark S.; Pazzaglia, Peggy J.; Jerrels, Shari A.; Post, Robert M.; Freed, William J.

In: Journal of Neurochemistry, Vol. 66, No. 4, 04.1996, p. 1532-1538.

Research output: Contribution to journalArticle

Poltorak, M, Frye, MA, Wright, R, Hemperly, JJ, George, MS, Pazzaglia, PJ, Jerrels, SA, Post, RM & Freed, WJ 1996, 'Increased neural cell adhesion molecule in the CSF of patients with mood disorder', Journal of Neurochemistry, vol. 66, no. 4, pp. 1532-1538.
Poltorak M, Frye MA, Wright R, Hemperly JJ, George MS, Pazzaglia PJ et al. Increased neural cell adhesion molecule in the CSF of patients with mood disorder. Journal of Neurochemistry. 1996 Apr;66(4):1532-1538.
Poltorak, Maciej ; Frye, Mark A ; Wright, Renee ; Hemperly, John J. ; George, Mark S. ; Pazzaglia, Peggy J. ; Jerrels, Shari A. ; Post, Robert M. ; Freed, William J. / Increased neural cell adhesion molecule in the CSF of patients with mood disorder. In: Journal of Neurochemistry. 1996 ; Vol. 66, No. 4. pp. 1532-1538.
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