Increased leukotriene E4 excretion in systemic mastocytosis

Joseph H. Butterfield

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Cysteinyl leukotrienes such as LTE4 are produced by mast cells, neutrophils, eosinophils, and macrophages. LTE4 levels have not been reported in systemic mastocytosis, a disorder with a large increase in mast cell numbers. Urinary LTE4 from patients referred for symptoms potentially due to mast cell degranulation or systemic mastocytosis was measured by a commercial cysteinyl leukotriene enzyme immunoassay kit. The diagnosis of systemic mastocytosis was established using current World Health Organization criteria. Compared with a control group of patients with various potential mast cell-related symptoms (e.g., "spells"), patients with systemic mastocytosis had a significant (P = .01) increase in urinary LTE4 excretion, whether expressed as LTE4 ng/g creatinine or as LTE4 ng/24 h. There was a moderate correlation of LTE4 ng/24 h with excretion of N-methyl histamine and serum tryptase but not with urinary 11β-prostaglandin F (11β-PGF) excretion. LTE4 excretion is increased in patients with systemic mastocytosis and potentially contributes to clinical symptoms.

Original languageEnglish (US)
Pages (from-to)73-76
Number of pages4
JournalProstaglandins and Other Lipid Mediators
Volume92
Issue number1-4
DOIs
StatePublished - Jun 1 2010

Keywords

  • Leukotriene E
  • Mast cells
  • Systemic mastocytosis

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Cell Biology

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