Increased incidence and recurrence rates of nonmelanoma skin cancer in patients with non-Hodgkin lymphoma: A Rochester epidemiology project population-based study in Minnesota

Jerry D. Brewer; Tait D. Shanafelt; Farzaneh Khezri; Ivette M. Sosa Seda; Adeel S. Zubair; Christian L. Baum; Christopher J. Arpey; James R. Cerhan; Timothy G. Call; Randall K. Roenigk; Carin Y. Smith; Amy L. Weaver; Clark C. Otley

doi:10.1016/j.jaad.2014.10.028

Increased incidence and recurrence rates of nonmelanoma skin cancer in patients with non-Hodgkin lymphoma: A Rochester epidemiology project population-based study in Minnesota

Jerry D. Brewer, Tait D. Shanafelt, Farzaneh Khezri, Ivette M. Sosa Seda, Adeel S. Zubair, Christian L. Baum, Christopher J. Arpey, James R. Cerhan, Timothy G. Call, Randall K. Roenigk, Carin Y. Smith, Amy L. Weaver, Clark C. Otley

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43 Scopus citations

Abstract

Background: Cutaneous malignancy is associated with worse outcomes in patients with chronic lymphocytic leukemia (CLL). Objective: We sought to identify the incidence and recurrence rate of nonmelanoma skin cancer (NMSC) in patients with non-Hodgkin lymphoma (NHL). Methods: NMSC incidence was calculated and Cox proportional hazards models were used to evaluate associations with risk of recurrence for patients with NHL between 1976 and 2005 who were in the Rochester Epidemiology Project research infrastructure. Results: We identified 282 patients with CLL or small lymphocytic lymphoma and 435 with non-CLL NHL. The incidence of basal cell carcinoma and squamous cell carcinoma was 1829.3 (95% confidence interval [CI] 1306.7-2491.1) and 2224.9 (95% CI 1645.9-2941.6), respectively, in patients with CLL. The cumulative recurrence rate at 8 years after treatment with Mohs micrographic surgery was 8.3% (95% CI 0.0%-22.7%) for basal cell carcinoma and 13.4% (95% CI 0.0%-25.5%) for squamous cell carcinoma in patients with CLL. Limitations: This was a retrospective cohort study. Conclusions: After Mohs micrographic surgery and standard excision of NMSC, patients with NHL had a skin cancer recurrence rate that was higher than expected. Careful treatment and monitoring of patients with NHL and NMSC are warranted.

Original language	English (US)
Pages (from-to)	302-309
Number of pages	8
Journal	Journal of the American Academy of Dermatology
Volume	72
Issue number	2
DOIs	https://doi.org/10.1016/j.jaad.2014.10.028
State	Published - 2015

Keywords

Chronic lymphocytic leukemia
Immunosuppression
Malignant melanoma
Mohs micrographic surgery

ASJC Scopus subject areas

Dermatology

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10.1016/j.jaad.2014.10.028

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Brewer, J. D., Shanafelt, T. D., Khezri, F., Sosa Seda, I. M., Zubair, A. S., Baum, C. L., Arpey, C. J., Cerhan, J. R., Call, T. G., Roenigk, R. K., Smith, C. Y., Weaver, A. L., & Otley, C. C. (2015). Increased incidence and recurrence rates of nonmelanoma skin cancer in patients with non-Hodgkin lymphoma: A Rochester epidemiology project population-based study in Minnesota. Journal of the American Academy of Dermatology, 72(2), 302-309. https://doi.org/10.1016/j.jaad.2014.10.028

Increased incidence and recurrence rates of nonmelanoma skin cancer in patients with non-Hodgkin lymphoma: A Rochester epidemiology project population-based study in Minnesota. / Brewer, Jerry D.; Shanafelt, Tait D.; Khezri, Farzaneh et al.
In: Journal of the American Academy of Dermatology, Vol. 72, No. 2, 2015, p. 302-309.

Research output: Contribution to journal › Article › peer-review

Brewer, JD, Shanafelt, TD, Khezri, F, Sosa Seda, IM, Zubair, AS, Baum, CL, Arpey, CJ, Cerhan, JR, Call, TG, Roenigk, RK, Smith, CY, Weaver, AL & Otley, CC 2015, 'Increased incidence and recurrence rates of nonmelanoma skin cancer in patients with non-Hodgkin lymphoma: A Rochester epidemiology project population-based study in Minnesota', Journal of the American Academy of Dermatology, vol. 72, no. 2, pp. 302-309. https://doi.org/10.1016/j.jaad.2014.10.028

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title = "Increased incidence and recurrence rates of nonmelanoma skin cancer in patients with non-Hodgkin lymphoma: A Rochester epidemiology project population-based study in Minnesota",

abstract = "Background: Cutaneous malignancy is associated with worse outcomes in patients with chronic lymphocytic leukemia (CLL). Objective: We sought to identify the incidence and recurrence rate of nonmelanoma skin cancer (NMSC) in patients with non-Hodgkin lymphoma (NHL). Methods: NMSC incidence was calculated and Cox proportional hazards models were used to evaluate associations with risk of recurrence for patients with NHL between 1976 and 2005 who were in the Rochester Epidemiology Project research infrastructure. Results: We identified 282 patients with CLL or small lymphocytic lymphoma and 435 with non-CLL NHL. The incidence of basal cell carcinoma and squamous cell carcinoma was 1829.3 (95% confidence interval [CI] 1306.7-2491.1) and 2224.9 (95% CI 1645.9-2941.6), respectively, in patients with CLL. The cumulative recurrence rate at 8 years after treatment with Mohs micrographic surgery was 8.3% (95% CI 0.0%-22.7%) for basal cell carcinoma and 13.4% (95% CI 0.0%-25.5%) for squamous cell carcinoma in patients with CLL. Limitations: This was a retrospective cohort study. Conclusions: After Mohs micrographic surgery and standard excision of NMSC, patients with NHL had a skin cancer recurrence rate that was higher than expected. Careful treatment and monitoring of patients with NHL and NMSC are warranted.",

keywords = "Chronic lymphocytic leukemia, Immunosuppression, Malignant melanoma, Mohs micrographic surgery",

author = "Brewer, {Jerry D.} and Shanafelt, {Tait D.} and Farzaneh Khezri and {Sosa Seda}, {Ivette M.} and Zubair, {Adeel S.} and Baum, {Christian L.} and Arpey, {Christopher J.} and Cerhan, {James R.} and Call, {Timothy G.} and Roenigk, {Randall K.} and Smith, {Carin Y.} and Weaver, {Amy L.} and Otley, {Clark C.}",

year = "2015",

doi = "10.1016/j.jaad.2014.10.028",

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T1 - Increased incidence and recurrence rates of nonmelanoma skin cancer in patients with non-Hodgkin lymphoma

T2 - A Rochester epidemiology project population-based study in Minnesota

AU - Brewer, Jerry D.

AU - Shanafelt, Tait D.

AU - Khezri, Farzaneh

AU - Sosa Seda, Ivette M.

AU - Zubair, Adeel S.

AU - Baum, Christian L.

AU - Arpey, Christopher J.

AU - Cerhan, James R.

AU - Call, Timothy G.

AU - Roenigk, Randall K.

AU - Smith, Carin Y.

AU - Weaver, Amy L.

AU - Otley, Clark C.

PY - 2015

Y1 - 2015

N2 - Background: Cutaneous malignancy is associated with worse outcomes in patients with chronic lymphocytic leukemia (CLL). Objective: We sought to identify the incidence and recurrence rate of nonmelanoma skin cancer (NMSC) in patients with non-Hodgkin lymphoma (NHL). Methods: NMSC incidence was calculated and Cox proportional hazards models were used to evaluate associations with risk of recurrence for patients with NHL between 1976 and 2005 who were in the Rochester Epidemiology Project research infrastructure. Results: We identified 282 patients with CLL or small lymphocytic lymphoma and 435 with non-CLL NHL. The incidence of basal cell carcinoma and squamous cell carcinoma was 1829.3 (95% confidence interval [CI] 1306.7-2491.1) and 2224.9 (95% CI 1645.9-2941.6), respectively, in patients with CLL. The cumulative recurrence rate at 8 years after treatment with Mohs micrographic surgery was 8.3% (95% CI 0.0%-22.7%) for basal cell carcinoma and 13.4% (95% CI 0.0%-25.5%) for squamous cell carcinoma in patients with CLL. Limitations: This was a retrospective cohort study. Conclusions: After Mohs micrographic surgery and standard excision of NMSC, patients with NHL had a skin cancer recurrence rate that was higher than expected. Careful treatment and monitoring of patients with NHL and NMSC are warranted.

AB - Background: Cutaneous malignancy is associated with worse outcomes in patients with chronic lymphocytic leukemia (CLL). Objective: We sought to identify the incidence and recurrence rate of nonmelanoma skin cancer (NMSC) in patients with non-Hodgkin lymphoma (NHL). Methods: NMSC incidence was calculated and Cox proportional hazards models were used to evaluate associations with risk of recurrence for patients with NHL between 1976 and 2005 who were in the Rochester Epidemiology Project research infrastructure. Results: We identified 282 patients with CLL or small lymphocytic lymphoma and 435 with non-CLL NHL. The incidence of basal cell carcinoma and squamous cell carcinoma was 1829.3 (95% confidence interval [CI] 1306.7-2491.1) and 2224.9 (95% CI 1645.9-2941.6), respectively, in patients with CLL. The cumulative recurrence rate at 8 years after treatment with Mohs micrographic surgery was 8.3% (95% CI 0.0%-22.7%) for basal cell carcinoma and 13.4% (95% CI 0.0%-25.5%) for squamous cell carcinoma in patients with CLL. Limitations: This was a retrospective cohort study. Conclusions: After Mohs micrographic surgery and standard excision of NMSC, patients with NHL had a skin cancer recurrence rate that was higher than expected. Careful treatment and monitoring of patients with NHL and NMSC are warranted.

KW - Chronic lymphocytic leukemia

KW - Immunosuppression

KW - Malignant melanoma

KW - Mohs micrographic surgery

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Increased incidence and recurrence rates of nonmelanoma skin cancer in patients with non-Hodgkin lymphoma: A Rochester epidemiology project population-based study in Minnesota

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