Increased immunoglobulin (Ig) G4-positive plasma cell density and IgG4/IgG ratio are not specific for IgG4-related disease in the skin.

Julia Lehman, Thomas Christopher Smyrk, Mark R. Pittelkow

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Immunoglobulin (Ig) G4-related disease (IgG4-RD), a fibroinflammatory condition that can affect multiple organs, is suggested by lymphoplasmacytic inflammation, fibrosis, phlebitis, and increased IgG4+ plasma cell (PC) tissue density. In patients with suspected IgG4-RD and skin changes, skin biopsy may serve as a diagnostic screen or to supplement nondiagnostic visceral biopsy specimens. We aimed to determine whether increased cutaneous IgG4+ PCs or IgG4/IgG ratio is specific for IgG4-RD. We examined 50 mucocutaneous specimens representing seven PC-rich dermatoses and reactive PC-rich infiltrates with IgG and IgG4 immunohistochemical stains. IgG4+ density exceeded 10 cells per high-power field in 22 (44%) of 50 specimens, representing six of seven diagnoses and reactive infiltrates. In five specimens (10%), the IgG4/IgG ratio exceeded 0.40. Moderately elevated IgG4+ PC density or IgG4/IgG ratio is a nonspecific finding in the skin. In cutaneous biopsy specimens showing increased IgG4+ PCs, careful consideration should be given to clinical, serologic, and other histopathologic features before attributing clinical changes to IgG4-RD.

Original languageEnglish (US)
Pages (from-to)234-238
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume141
Issue number2
DOIs
StatePublished - Feb 2014

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Plasma Cells
Skin Diseases
Immunoglobulins
Cell Count
Immunoglobulin G
Skin
Biopsy
Phlebitis
Fibrosis
Coloring Agents
Inflammation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Increased immunoglobulin (Ig) G4-positive plasma cell density and IgG4/IgG ratio are not specific for IgG4-related disease in the skin. / Lehman, Julia; Smyrk, Thomas Christopher; Pittelkow, Mark R.

In: American Journal of Clinical Pathology, Vol. 141, No. 2, 02.2014, p. 234-238.

Research output: Contribution to journalArticle

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