Increased IgG4-positive plasma cells in granulomatosis with polyangiitis: A diagnostic pitfall of IgG4-related disease

Sing Yun Chang, Karina Keogh, Jean E. Lewis, Jay H Ryu, Eunhee S. Yi

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Granulomatosis with polyangiitis (Wegener's) (GPA) may mimic IgG4-related disease (IgG4-RD) on histologic examination of some biopsies, especially those from head and neck sites. IgG4 immunostain is often performed in this context for differential diagnosis with IgG4-RD. However, the prevalence of IgG4+ cells in GPA has not been explored. We examined the IgG4+ cells in 26 cases confirmed as GPA by a thorough clinical and pathologic assessment. Twenty-six biopsies consisted of 14 sinonasal/oral cavity/nasopharynx, 7 orbit/periorbital, 3 lung/pleura, 1 iliac fossa/kidney, and 1 dura specimens. Eight of 26 (31) biopsies revealed increased IgG4+ cells (30/HPF and >40% in IgG4+/IgG+ ratio). The IgG4+ cells and IgG4+/IgG+ ratio ranged 37-137/hpf and 44-83, respectively. Eight biopsies with increased IgG4+ cells were from sinonasal (n=4) or orbital/periorbital (n=4) sites. In conclusion, increased IgG4+ cells are not uncommonly seen in sinonasal or orbital/periorbital biopsies of GPA, which could pose as a diagnostic pitfall.

Original languageEnglish (US)
Article number121702
JournalInternational Journal of Rheumatology
Volume2012
DOIs
StatePublished - 2012

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Granulomatosis with Polyangiitis
Plasma Cells
Immunoglobulin G
Biopsy
Nasopharynx
Pleura
Orbit
Mouth
Differential Diagnosis
Neck

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Increased IgG4-positive plasma cells in granulomatosis with polyangiitis : A diagnostic pitfall of IgG4-related disease. / Chang, Sing Yun; Keogh, Karina; Lewis, Jean E.; Ryu, Jay H; Yi, Eunhee S.

In: International Journal of Rheumatology, Vol. 2012, 121702, 2012.

Research output: Contribution to journalArticle

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abstract = "Granulomatosis with polyangiitis (Wegener's) (GPA) may mimic IgG4-related disease (IgG4-RD) on histologic examination of some biopsies, especially those from head and neck sites. IgG4 immunostain is often performed in this context for differential diagnosis with IgG4-RD. However, the prevalence of IgG4+ cells in GPA has not been explored. We examined the IgG4+ cells in 26 cases confirmed as GPA by a thorough clinical and pathologic assessment. Twenty-six biopsies consisted of 14 sinonasal/oral cavity/nasopharynx, 7 orbit/periorbital, 3 lung/pleura, 1 iliac fossa/kidney, and 1 dura specimens. Eight of 26 (31) biopsies revealed increased IgG4+ cells (30/HPF and >40{\%} in IgG4+/IgG+ ratio). The IgG4+ cells and IgG4+/IgG+ ratio ranged 37-137/hpf and 44-83, respectively. Eight biopsies with increased IgG4+ cells were from sinonasal (n=4) or orbital/periorbital (n=4) sites. In conclusion, increased IgG4+ cells are not uncommonly seen in sinonasal or orbital/periorbital biopsies of GPA, which could pose as a diagnostic pitfall.",
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