Increased high-frequency oscillations precede in vitro low-Mg2+ seizures

Houman Khosravani, C. Robert Pinnegar, Joseph Ross Mitchell, Berj L. Bardakjian, Paolo Federico, Peter L. Carlen

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Purpose: High-frequency oscillations (HFOs) in the range of ≥80 Hz have been recorded in neocortical and hippocampal brain structures in vitro and in vivo and have been associated with physiologic and epileptiform neuronal population activity. Frequencies in the fast-ripple range (>200 Hz) are believed to be exclusive to epileptiform activity and have been recorded in vitro, in vivo, and in epilepsy patients. Although the presence of HFOs is well characterized, their temporal evolution in the context of transition to seizure activity is not well understood. Methods: With an in vitro low-magnesium model of spontaneous seizures, we obtained extracellular field recordings (hippocampal regions CA1 and CA3) of interictal, preictal, and ictal activity. Recordings were subjected to power-frequency analysis, in time, by using a local multiscale Fourier transform. The power spectrum was computed continuously and was quantified for each epileptiform discharge into four frequency ranges spanning subripple, ripple, and two fast-ripple frequency bands. Results: A statistically significant increasing trend was observed in the subripple (0-100 Hz), ripple (100-200 Hz), and fast-ripple 1 (200-300 Hz) frequency bands during the epoch corresponding to the transition to seizure (preictal to ictal). Conclusions: Temporal patterns of HFOs during epileptiform activity are indicative of dynamic changes in network behavior, and their characterization may offer insights into pathophysiologic processes underlying seizure initiation.

Original languageEnglish (US)
Pages (from-to)1188-1197
Number of pages10
JournalEpilepsia
Volume46
Issue number8
DOIs
StatePublished - Aug 2005
Externally publishedYes

Fingerprint

Seizures
Stroke
Hippocampal CA3 Region
Hippocampal CA1 Region
Fourier Analysis
Magnesium
Epilepsy
In Vitro Techniques
Brain
Population

Keywords

  • Epilepsy
  • Ripples
  • Time-frequency-Preictal

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Khosravani, H., Pinnegar, C. R., Mitchell, J. R., Bardakjian, B. L., Federico, P., & Carlen, P. L. (2005). Increased high-frequency oscillations precede in vitro low-Mg2+ seizures. Epilepsia, 46(8), 1188-1197. https://doi.org/10.1111/j.1528-1167.2005.65604.x

Increased high-frequency oscillations precede in vitro low-Mg2+ seizures. / Khosravani, Houman; Pinnegar, C. Robert; Mitchell, Joseph Ross; Bardakjian, Berj L.; Federico, Paolo; Carlen, Peter L.

In: Epilepsia, Vol. 46, No. 8, 08.2005, p. 1188-1197.

Research output: Contribution to journalArticle

Khosravani, H, Pinnegar, CR, Mitchell, JR, Bardakjian, BL, Federico, P & Carlen, PL 2005, 'Increased high-frequency oscillations precede in vitro low-Mg2+ seizures', Epilepsia, vol. 46, no. 8, pp. 1188-1197. https://doi.org/10.1111/j.1528-1167.2005.65604.x
Khosravani H, Pinnegar CR, Mitchell JR, Bardakjian BL, Federico P, Carlen PL. Increased high-frequency oscillations precede in vitro low-Mg2+ seizures. Epilepsia. 2005 Aug;46(8):1188-1197. https://doi.org/10.1111/j.1528-1167.2005.65604.x
Khosravani, Houman ; Pinnegar, C. Robert ; Mitchell, Joseph Ross ; Bardakjian, Berj L. ; Federico, Paolo ; Carlen, Peter L. / Increased high-frequency oscillations precede in vitro low-Mg2+ seizures. In: Epilepsia. 2005 ; Vol. 46, No. 8. pp. 1188-1197.
@article{7b6e556ef8804e29bf0f9e6735864a5c,
title = "Increased high-frequency oscillations precede in vitro low-Mg2+ seizures",
abstract = "Purpose: High-frequency oscillations (HFOs) in the range of ≥80 Hz have been recorded in neocortical and hippocampal brain structures in vitro and in vivo and have been associated with physiologic and epileptiform neuronal population activity. Frequencies in the fast-ripple range (>200 Hz) are believed to be exclusive to epileptiform activity and have been recorded in vitro, in vivo, and in epilepsy patients. Although the presence of HFOs is well characterized, their temporal evolution in the context of transition to seizure activity is not well understood. Methods: With an in vitro low-magnesium model of spontaneous seizures, we obtained extracellular field recordings (hippocampal regions CA1 and CA3) of interictal, preictal, and ictal activity. Recordings were subjected to power-frequency analysis, in time, by using a local multiscale Fourier transform. The power spectrum was computed continuously and was quantified for each epileptiform discharge into four frequency ranges spanning subripple, ripple, and two fast-ripple frequency bands. Results: A statistically significant increasing trend was observed in the subripple (0-100 Hz), ripple (100-200 Hz), and fast-ripple 1 (200-300 Hz) frequency bands during the epoch corresponding to the transition to seizure (preictal to ictal). Conclusions: Temporal patterns of HFOs during epileptiform activity are indicative of dynamic changes in network behavior, and their characterization may offer insights into pathophysiologic processes underlying seizure initiation.",
keywords = "Epilepsy, Ripples, Time-frequency-Preictal",
author = "Houman Khosravani and Pinnegar, {C. Robert} and Mitchell, {Joseph Ross} and Bardakjian, {Berj L.} and Paolo Federico and Carlen, {Peter L.}",
year = "2005",
month = "8",
doi = "10.1111/j.1528-1167.2005.65604.x",
language = "English (US)",
volume = "46",
pages = "1188--1197",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Increased high-frequency oscillations precede in vitro low-Mg2+ seizures

AU - Khosravani, Houman

AU - Pinnegar, C. Robert

AU - Mitchell, Joseph Ross

AU - Bardakjian, Berj L.

AU - Federico, Paolo

AU - Carlen, Peter L.

PY - 2005/8

Y1 - 2005/8

N2 - Purpose: High-frequency oscillations (HFOs) in the range of ≥80 Hz have been recorded in neocortical and hippocampal brain structures in vitro and in vivo and have been associated with physiologic and epileptiform neuronal population activity. Frequencies in the fast-ripple range (>200 Hz) are believed to be exclusive to epileptiform activity and have been recorded in vitro, in vivo, and in epilepsy patients. Although the presence of HFOs is well characterized, their temporal evolution in the context of transition to seizure activity is not well understood. Methods: With an in vitro low-magnesium model of spontaneous seizures, we obtained extracellular field recordings (hippocampal regions CA1 and CA3) of interictal, preictal, and ictal activity. Recordings were subjected to power-frequency analysis, in time, by using a local multiscale Fourier transform. The power spectrum was computed continuously and was quantified for each epileptiform discharge into four frequency ranges spanning subripple, ripple, and two fast-ripple frequency bands. Results: A statistically significant increasing trend was observed in the subripple (0-100 Hz), ripple (100-200 Hz), and fast-ripple 1 (200-300 Hz) frequency bands during the epoch corresponding to the transition to seizure (preictal to ictal). Conclusions: Temporal patterns of HFOs during epileptiform activity are indicative of dynamic changes in network behavior, and their characterization may offer insights into pathophysiologic processes underlying seizure initiation.

AB - Purpose: High-frequency oscillations (HFOs) in the range of ≥80 Hz have been recorded in neocortical and hippocampal brain structures in vitro and in vivo and have been associated with physiologic and epileptiform neuronal population activity. Frequencies in the fast-ripple range (>200 Hz) are believed to be exclusive to epileptiform activity and have been recorded in vitro, in vivo, and in epilepsy patients. Although the presence of HFOs is well characterized, their temporal evolution in the context of transition to seizure activity is not well understood. Methods: With an in vitro low-magnesium model of spontaneous seizures, we obtained extracellular field recordings (hippocampal regions CA1 and CA3) of interictal, preictal, and ictal activity. Recordings were subjected to power-frequency analysis, in time, by using a local multiscale Fourier transform. The power spectrum was computed continuously and was quantified for each epileptiform discharge into four frequency ranges spanning subripple, ripple, and two fast-ripple frequency bands. Results: A statistically significant increasing trend was observed in the subripple (0-100 Hz), ripple (100-200 Hz), and fast-ripple 1 (200-300 Hz) frequency bands during the epoch corresponding to the transition to seizure (preictal to ictal). Conclusions: Temporal patterns of HFOs during epileptiform activity are indicative of dynamic changes in network behavior, and their characterization may offer insights into pathophysiologic processes underlying seizure initiation.

KW - Epilepsy

KW - Ripples

KW - Time-frequency-Preictal

UR - http://www.scopus.com/inward/record.url?scp=23944438971&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23944438971&partnerID=8YFLogxK

U2 - 10.1111/j.1528-1167.2005.65604.x

DO - 10.1111/j.1528-1167.2005.65604.x

M3 - Article

C2 - 16060927

AN - SCOPUS:23944438971

VL - 46

SP - 1188

EP - 1197

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - 8

ER -