Increased expression of the retinoblastoma gene in human colorectal carcinomas relative to normal colonic mucosa

Rajalakshmi Gope, Mark A. Christensen, Alan Thorson, Henry T. Lynch, Thomas Christopher Smyrk, Clague Hodgson, David M. Wildrick, Mohan L. Gope, Bruce M. Boman

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

We report the first evidence of increased levels of the retinoblastoma (Rb) message in a majority of colorectal cancers when compared with normal mucosa. Southern blot analysis showed an increase in Rb gene copy number in at least 28% of colorectal carcinomas relative to normal mucosa. These results plus previous reports of nonrandom chromosome 13 gains in approximately 50% of colorectal cancers suggest that an increase in Rb gene copy number occurs frequently in these tumors. Possible mechanisms pertaining to overexpression of the Rb gene are discussed in relation to its role as a recessive cancer gene.

Original languageEnglish (US)
Pages (from-to)310-314
Number of pages5
JournalJournal of the National Cancer Institute
Volume82
Issue number4
StatePublished - Feb 21 1990
Externally publishedYes

Fingerprint

Retinoblastoma Genes
Colorectal Neoplasms
Mucous Membrane
Gene Dosage
Genes
Gene
Colorectal Cancer
Recessive Genes
Chromosomes, Human, Pair 13
Retinoblastoma
Neoplasm Genes
Southern Blotting
Chromosomes
Chromosome
Tumors
Tumor
Cancer
Human
Neoplasms
Colorectal cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging

Cite this

Gope, R., Christensen, M. A., Thorson, A., Lynch, H. T., Smyrk, T. C., Hodgson, C., ... Boman, B. M. (1990). Increased expression of the retinoblastoma gene in human colorectal carcinomas relative to normal colonic mucosa. Journal of the National Cancer Institute, 82(4), 310-314.

Increased expression of the retinoblastoma gene in human colorectal carcinomas relative to normal colonic mucosa. / Gope, Rajalakshmi; Christensen, Mark A.; Thorson, Alan; Lynch, Henry T.; Smyrk, Thomas Christopher; Hodgson, Clague; Wildrick, David M.; Gope, Mohan L.; Boman, Bruce M.

In: Journal of the National Cancer Institute, Vol. 82, No. 4, 21.02.1990, p. 310-314.

Research output: Contribution to journalArticle

Gope, R, Christensen, MA, Thorson, A, Lynch, HT, Smyrk, TC, Hodgson, C, Wildrick, DM, Gope, ML & Boman, BM 1990, 'Increased expression of the retinoblastoma gene in human colorectal carcinomas relative to normal colonic mucosa', Journal of the National Cancer Institute, vol. 82, no. 4, pp. 310-314.
Gope R, Christensen MA, Thorson A, Lynch HT, Smyrk TC, Hodgson C et al. Increased expression of the retinoblastoma gene in human colorectal carcinomas relative to normal colonic mucosa. Journal of the National Cancer Institute. 1990 Feb 21;82(4):310-314.
Gope, Rajalakshmi ; Christensen, Mark A. ; Thorson, Alan ; Lynch, Henry T. ; Smyrk, Thomas Christopher ; Hodgson, Clague ; Wildrick, David M. ; Gope, Mohan L. ; Boman, Bruce M. / Increased expression of the retinoblastoma gene in human colorectal carcinomas relative to normal colonic mucosa. In: Journal of the National Cancer Institute. 1990 ; Vol. 82, No. 4. pp. 310-314.
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