Increased endoneurial albumin in diabetic polyneuropathy

Takekazu Ohi; Joseph F. Poduslo; Peter J. Dyck

doi:10.1212/wnl.35.12.1790

Increased endoneurial albumin in diabetic polyneuropathy

Takekazu Ohi, Joseph F. Poduslo, Peter J. Dyck

Neurology

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Albumin was measured in the endoneurium of fascicular biopsies of sural nerves and in plasma from diabetic patients with polyneuropathy by solid phase radioimmunoassay, and normalized to total endoneurial and plasma protein, respectively, to obtain an index of the blood-nerve barrier (BNB-Index). Fifteen diabetic patients with polyneuropathy had a mean BNB-Index of 29.7 ± 12.6% SD, 3.8 times higherthan control values (7.8 ± 2.0% SD, n = 4).These data suggest that the blood-nerve barrier of endoneurial capillaries is impaired in patients with diabetic polyneuropathy.

Original language	English (US)
Pages (from-to)	1790-1791
Number of pages	2
Journal	Neurology
Volume	35
Issue number	12
DOIs	https://doi.org/10.1212/wnl.35.12.1790
State	Published - Dec 1985

ASJC Scopus subject areas

Clinical Neurology

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abstract = "Albumin was measured in the endoneurium of fascicular biopsies of sural nerves and in plasma from diabetic patients with polyneuropathy by solid phase radioimmunoassay, and normalized to total endoneurial and plasma protein, respectively, to obtain an index of the blood-nerve barrier (BNB-Index). Fifteen diabetic patients with polyneuropathy had a mean BNB-Index of 29.7 ± 12.6% SD, 3.8 times higherthan control values (7.8 ± 2.0% SD, n = 4).These data suggest that the blood-nerve barrier of endoneurial capillaries is impaired in patients with diabetic polyneuropathy.",

author = "Takekazu Ohi and Poduslo, {Joseph F.} and Dyck, {Peter J.}",

year = "1985",

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AU - Ohi, Takekazu

AU - Poduslo, Joseph F.

AU - Dyck, Peter J.

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N2 - Albumin was measured in the endoneurium of fascicular biopsies of sural nerves and in plasma from diabetic patients with polyneuropathy by solid phase radioimmunoassay, and normalized to total endoneurial and plasma protein, respectively, to obtain an index of the blood-nerve barrier (BNB-Index). Fifteen diabetic patients with polyneuropathy had a mean BNB-Index of 29.7 ± 12.6% SD, 3.8 times higherthan control values (7.8 ± 2.0% SD, n = 4).These data suggest that the blood-nerve barrier of endoneurial capillaries is impaired in patients with diabetic polyneuropathy.

AB - Albumin was measured in the endoneurium of fascicular biopsies of sural nerves and in plasma from diabetic patients with polyneuropathy by solid phase radioimmunoassay, and normalized to total endoneurial and plasma protein, respectively, to obtain an index of the blood-nerve barrier (BNB-Index). Fifteen diabetic patients with polyneuropathy had a mean BNB-Index of 29.7 ± 12.6% SD, 3.8 times higherthan control values (7.8 ± 2.0% SD, n = 4).These data suggest that the blood-nerve barrier of endoneurial capillaries is impaired in patients with diabetic polyneuropathy.

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Increased endoneurial albumin in diabetic polyneuropathy

Abstract

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