Increased endoneurial albumin in diabetic polyneuropathy

Takekazu Ohi, Joseph F. Poduslo, Peter J. Dyck

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Albumin was measured in the endoneurium of fascicular biopsies of sural nerves and in plasma from diabetic patients with polyneuropathy by solid phase radioimmunoassay, and normalized to total endoneurial and plasma protein, respectively, to obtain an index of the blood-nerve barrier (BNB-Index). Fifteen diabetic patients with polyneuropathy had a mean BNB-Index of 29.7 ± 12.6% SD, 3.8 times higherthan control values (7.8 ± 2.0% SD, n = 4).These data suggest that the blood-nerve barrier of endoneurial capillaries is impaired in patients with diabetic polyneuropathy.

Original languageEnglish (US)
Pages (from-to)1790-1791
Number of pages2
JournalNeurology
Volume35
Issue number12
DOIs
StatePublished - Dec 1985

ASJC Scopus subject areas

  • Clinical Neurology

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