Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer

Mabel Ryder, Ronald A. Ghossein, Julio C M Ricarte-Filho, Jeffrey A. Knauf, James A. Fagin

Research output: Contribution to journalArticle

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Abstract

Thyroid cancers are infiltrated with tumor-associated macrophages (TAMS), yet their role in cancer progression is not known. The objectives of this study were to characterize the density of TAMs in well-differentiated (WDTC), poorly differentiated (PDTC), and anaplastic thyroid cancers (ATC) and to correlate TAM density with clinicopathologic parameters. Immunohistochemistry was performed on tissue microarray sections from WIDTC (n=33), PDTC (n=37), and ATC (n=20) using macrophage-specific markers. Electronic medical records were used to gather clinical and pathologic data. Follow-up information of PDTC patients was available for 0-12 years. In total, 9 out of 33 WDTC (27%), 20 out of 37 PDTC (54%), and 19 out of 20 ATC (95%) had an increased density of CD68+ TAMs (≥ 10 per 0.28 MM2; WDTC versus PDTC, P=0.03; WDTC versus ATC, P<0.0001; PIDTC versus ATC, P<0.002). Increased TAMs in PDTC was associated with capsular invasion (P=0.034), extrathyroidal extension (P=0.009), and decreased cancer-related survival (P=0.009) compared with PDTC with a low density of TAMs. In conclusion, the density of TAMs is increased in advanced thyroid cancers. The presence of a high density of TAMs in PDTC correlates with invasion and decreased cancer-related survival. These results suggest that TAMs may facilitate tumor progression. As novel therapies directed against thyroid tumor cell-specific targets are being tested, the potential role of TAMs as potential modulators of the thyroid cancer behavior will need to be considered.

Original languageEnglish (US)
Pages (from-to)1069-1074
Number of pages6
JournalEndocrine-Related Cancer
Volume15
Issue number4
DOIs
StatePublished - Dec 2008
Externally publishedYes

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Thyroid Neoplasms
Macrophages
Survival
Neoplasms
prolinedithiocarbamate
Electronic Health Records
Thyroid Gland
Immunohistochemistry
Anaplastic Thyroid Carcinoma

ASJC Scopus subject areas

  • Endocrinology
  • Oncology
  • Cancer Research
  • Endocrinology, Diabetes and Metabolism

Cite this

Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer. / Ryder, Mabel; Ghossein, Ronald A.; Ricarte-Filho, Julio C M; Knauf, Jeffrey A.; Fagin, James A.

In: Endocrine-Related Cancer, Vol. 15, No. 4, 12.2008, p. 1069-1074.

Research output: Contribution to journalArticle

Ryder, Mabel ; Ghossein, Ronald A. ; Ricarte-Filho, Julio C M ; Knauf, Jeffrey A. ; Fagin, James A. / Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer. In: Endocrine-Related Cancer. 2008 ; Vol. 15, No. 4. pp. 1069-1074.
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abstract = "Thyroid cancers are infiltrated with tumor-associated macrophages (TAMS), yet their role in cancer progression is not known. The objectives of this study were to characterize the density of TAMs in well-differentiated (WDTC), poorly differentiated (PDTC), and anaplastic thyroid cancers (ATC) and to correlate TAM density with clinicopathologic parameters. Immunohistochemistry was performed on tissue microarray sections from WIDTC (n=33), PDTC (n=37), and ATC (n=20) using macrophage-specific markers. Electronic medical records were used to gather clinical and pathologic data. Follow-up information of PDTC patients was available for 0-12 years. In total, 9 out of 33 WDTC (27{\%}), 20 out of 37 PDTC (54{\%}), and 19 out of 20 ATC (95{\%}) had an increased density of CD68+ TAMs (≥ 10 per 0.28 MM2; WDTC versus PDTC, P=0.03; WDTC versus ATC, P<0.0001; PIDTC versus ATC, P<0.002). Increased TAMs in PDTC was associated with capsular invasion (P=0.034), extrathyroidal extension (P=0.009), and decreased cancer-related survival (P=0.009) compared with PDTC with a low density of TAMs. In conclusion, the density of TAMs is increased in advanced thyroid cancers. The presence of a high density of TAMs in PDTC correlates with invasion and decreased cancer-related survival. These results suggest that TAMs may facilitate tumor progression. As novel therapies directed against thyroid tumor cell-specific targets are being tested, the potential role of TAMs as potential modulators of the thyroid cancer behavior will need to be considered.",
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