Increased CD38 expression is associated with favorable prognosis in adult acute leukemia

Afsaneh Keyhani, Yang O. Huh, David Jendiroba, Lance Pagliaro, Jorge Cortez, Sherry Pierce, Michael Pearlman, Elihu Estey, Hagop Kantarjian, Emil J. Freireich

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

CD38 is expressed in acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia (AML) blasts and its prognostic significance is unknown. We investigated CD38 expression in 304 AML and 138 ALL patients. CD38 was lower in AML-M3 compared to other FAB subtypes (5% vs. 41%; P<0.001), but was similar among ALL subtypes (56.6%; P=0.69). Ph+ ALL and AML with t(15;17) patients showed lower CD38 expression than the other cytogenetic groups. Overall survival favored AML and ALL patients with higher CD38 levels. Multivariate analysis revealed CD38 expression to be an independent outcome predictor in AML, but not in ALL.

Original languageEnglish (US)
Pages (from-to)153-159
Number of pages7
JournalLeukemia Research
Volume24
Issue number2
DOIs
StatePublished - Feb 2000

Keywords

  • Acute leukemia
  • CD38
  • Clinical outcome
  • Prognosis
  • Survival

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Keyhani, A., Huh, Y. O., Jendiroba, D., Pagliaro, L., Cortez, J., Pierce, S., Pearlman, M., Estey, E., Kantarjian, H., & Freireich, E. J. (2000). Increased CD38 expression is associated with favorable prognosis in adult acute leukemia. Leukemia Research, 24(2), 153-159. https://doi.org/10.1016/S0145-2126(99)00147-2