Increased Bone Marrow Plasma-Cell Percentage Predicts Outcomes in Newly Diagnosed Multiple Myeloma Patients

Abdullah S. Al Saleh; Harsh V. Parmar; Alissa Visram; Eli Muchtar; Francis K. Buadi; Ronald S. Go; Angela Dispenzieri; Prashant Kapoor; Rahma Warsame; Martha Q. Lacy; David Dingli; Nelson Leung; Wilson I. Gonsalves; Taxiarchis V. Kourelis; Morie A. Gertz; Robert A. Kyle; S. Vincent Rajkumar; Shaji K. Kumar

doi:10.1016/j.clml.2020.03.012

Increased Bone Marrow Plasma-Cell Percentage Predicts Outcomes in Newly Diagnosed Multiple Myeloma Patients

Abdullah S. Al Saleh, Harsh V. Parmar, Alissa Visram, Eli Muchtar, Francis K. Buadi, Ronald S. Go, Angela Dispenzieri, Prashant Kapoor, Rahma Warsame, Martha Q. Lacy, David Dingli, Nelson Leung, Wilson I. Gonsalves, Taxiarchis V. Kourelis, Morie A. Gertz, Robert A. Kyle, S. Vincent Rajkumar, Shaji K. Kumar

Hematology

Research output: Contribution to journal › Article › peer-review

Abstract

In the current era, the impact of bone marrow plasma-cell percentage (BMPC%) at diagnosis of multiple myeloma (MM) is not well described. We evaluated the prognostic impact of BMPC% ≥ 60% versus < 60% in 1426 newly diagnosed MM patients. Median progression-free and overall survival were shorter for patients with BMPC% ≥ 60%, even in a multivariate analysis that included known prognostic factors for MM.

Original language	English (US)
Pages (from-to)	596-601
Number of pages	6
Journal	Clinical Lymphoma, Myeloma and Leukemia
Volume	20
Issue number	9
DOIs	https://doi.org/10.1016/j.clml.2020.03.012
State	Published - Sep 2020

Keywords

Outcome
Prognosis
Tumor burden

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.clml.2020.03.012

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Al Saleh, A. S., Parmar, H. V., Visram, A., Muchtar, E., Buadi, F. K., Go, R. S., Dispenzieri, A., Kapoor, P., Warsame, R., Lacy, M. Q., Dingli, D., Leung, N., Gonsalves, W. I., Kourelis, T. V., Gertz, M. A., Kyle, R. A., Rajkumar, S. V., & Kumar, S. K. (2020). Increased Bone Marrow Plasma-Cell Percentage Predicts Outcomes in Newly Diagnosed Multiple Myeloma Patients. Clinical Lymphoma, Myeloma and Leukemia, 20(9), 596-601. https://doi.org/10.1016/j.clml.2020.03.012

Al Saleh, AS, Parmar, HV, Visram, A, Muchtar, E, Buadi, FK, Go, RS, Dispenzieri, A , Kapoor, P, Warsame, R, Lacy, MQ , Dingli, D, Leung, N, Gonsalves, WI , Kourelis, TV , Gertz, MA, Kyle, RA, Rajkumar, SV & Kumar, SK 2020, 'Increased Bone Marrow Plasma-Cell Percentage Predicts Outcomes in Newly Diagnosed Multiple Myeloma Patients', Clinical Lymphoma, Myeloma and Leukemia, vol. 20, no. 9, pp. 596-601. https://doi.org/10.1016/j.clml.2020.03.012

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title = "Increased Bone Marrow Plasma-Cell Percentage Predicts Outcomes in Newly Diagnosed Multiple Myeloma Patients",

abstract = "In the current era, the impact of bone marrow plasma-cell percentage (BMPC%) at diagnosis of multiple myeloma (MM) is not well described. We evaluated the prognostic impact of BMPC% ≥ 60% versus < 60% in 1426 newly diagnosed MM patients. Median progression-free and overall survival were shorter for patients with BMPC% ≥ 60%, even in a multivariate analysis that included known prognostic factors for MM.",

keywords = "Outcome, Prognosis, Tumor burden",

author = "{Al Saleh}, {Abdullah S.} and Parmar, {Harsh V.} and Alissa Visram and Eli Muchtar and Buadi, {Francis K.} and Go, {Ronald S.} and Angela Dispenzieri and Prashant Kapoor and Rahma Warsame and Lacy, {Martha Q.} and David Dingli and Nelson Leung and Gonsalves, {Wilson I.} and Kourelis, {Taxiarchis V.} and Gertz, {Morie A.} and Kyle, {Robert A.} and Rajkumar, {S. Vincent} and Kumar, {Shaji K.}",

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year = "2020",

month = sep,

doi = "10.1016/j.clml.2020.03.012",

language = "English (US)",

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AU - Al Saleh, Abdullah S.

AU - Parmar, Harsh V.

AU - Visram, Alissa

AU - Muchtar, Eli

AU - Buadi, Francis K.

AU - Go, Ronald S.

AU - Dispenzieri, Angela

AU - Kapoor, Prashant

AU - Warsame, Rahma

AU - Lacy, Martha Q.

AU - Dingli, David

AU - Leung, Nelson

AU - Gonsalves, Wilson I.

AU - Kourelis, Taxiarchis V.

AU - Gertz, Morie A.

AU - Kyle, Robert A.

AU - Rajkumar, S. Vincent

AU - Kumar, Shaji K.

PY - 2020/9

Y1 - 2020/9

N2 - In the current era, the impact of bone marrow plasma-cell percentage (BMPC%) at diagnosis of multiple myeloma (MM) is not well described. We evaluated the prognostic impact of BMPC% ≥ 60% versus < 60% in 1426 newly diagnosed MM patients. Median progression-free and overall survival were shorter for patients with BMPC% ≥ 60%, even in a multivariate analysis that included known prognostic factors for MM.

AB - In the current era, the impact of bone marrow plasma-cell percentage (BMPC%) at diagnosis of multiple myeloma (MM) is not well described. We evaluated the prognostic impact of BMPC% ≥ 60% versus < 60% in 1426 newly diagnosed MM patients. Median progression-free and overall survival were shorter for patients with BMPC% ≥ 60%, even in a multivariate analysis that included known prognostic factors for MM.

KW - Outcome

KW - Prognosis

KW - Tumor burden

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Increased Bone Marrow Plasma-Cell Percentage Predicts Outcomes in Newly Diagnosed Multiple Myeloma Patients

Abstract

Keywords

ASJC Scopus subject areas

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