Increased basal and pulsatile secretion of FSH and LH in young men with 47,XXY or 46,XX karyotypes

Lise Aksglaede, Rikke Beck Jensen, Elisabeth Carlsen, Petra Kok, Daniel M. Keenan, Johannes D Veldhuis, Niels E. Skakkebæk, Anders Juul

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: The regulation of normal sexual maturation and reproductive function is dependent on a precise hormonal regulation at hypothalamic, pituitary, and gonadal levels. The aim of this study was to investigate the neuroendocrine integrity of the pituitary-gonadal axis in patients with primary testicular failure due to supernumerary X chromosomes. Design: Cross-sectional study. Methods: In this study, 7 untreated patients with primary gonadal insufficiency due to SRY-positive 46,XX (n=4) and 46,XXY karyotypes (n=3) aged 18.8 years and 25 age-matched healthy controls participated. Reproductive hormones, testicular size, and overnight LH and FSH serum profiles and overnight urine LH and FSH excretion were determined. Results: Basal LH and FSH secretion was elevated 6.3- and 25.4-fold respectively in the patients and the amount of LH and FSH secreted per burst were 2.0- and 6.6-fold elevated. We found significantly more LH but not FSH peaks per 24 h, as estimated by the Weibull λ analysis. There was no difference between approximate entropy ratios or Weibull λ analyses indicating comparable orderliness and regularity of LH and FSH secretion. Overnight urinary LH and FSH excretion was significantly elevated in patients compared with controls and correlated significantly with calculated total overnight LH and FSH secretion respectively, thus validating deconvolution. Conclusion: In this group of patients with severe hypergonadotropic hypogonadism due to a supernumerary X chromosome, higher basal, pulsatile, and total LH and FSH secretion were associated with significantly more LH peaks per 24 h in comparison with healthy controls. Thus, our data indicate that in patients with Klinefelter syndrome and XX male karyotypes the entire hypothalamic-pituitary-gonadal axis has undergone functional changes.

Original languageEnglish (US)
Pages (from-to)803-810
Number of pages8
JournalEuropean Journal of Endocrinology
Volume158
Issue number6
DOIs
StatePublished - Jun 2008

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Karyotype
X Chromosome
Testicular Hormones
Klinefelter Syndrome
Sexual Maturation
Hypogonadism
Entropy
Cross-Sectional Studies
Urine
Serum

ASJC Scopus subject areas

  • Endocrinology
  • Medicine(all)

Cite this

Aksglaede, L., Jensen, R. B., Carlsen, E., Kok, P., Keenan, D. M., Veldhuis, J. D., ... Juul, A. (2008). Increased basal and pulsatile secretion of FSH and LH in young men with 47,XXY or 46,XX karyotypes. European Journal of Endocrinology, 158(6), 803-810. https://doi.org/10.1530/EJE-07-0709

Increased basal and pulsatile secretion of FSH and LH in young men with 47,XXY or 46,XX karyotypes. / Aksglaede, Lise; Jensen, Rikke Beck; Carlsen, Elisabeth; Kok, Petra; Keenan, Daniel M.; Veldhuis, Johannes D; Skakkebæk, Niels E.; Juul, Anders.

In: European Journal of Endocrinology, Vol. 158, No. 6, 06.2008, p. 803-810.

Research output: Contribution to journalArticle

Aksglaede, L, Jensen, RB, Carlsen, E, Kok, P, Keenan, DM, Veldhuis, JD, Skakkebæk, NE & Juul, A 2008, 'Increased basal and pulsatile secretion of FSH and LH in young men with 47,XXY or 46,XX karyotypes', European Journal of Endocrinology, vol. 158, no. 6, pp. 803-810. https://doi.org/10.1530/EJE-07-0709
Aksglaede, Lise ; Jensen, Rikke Beck ; Carlsen, Elisabeth ; Kok, Petra ; Keenan, Daniel M. ; Veldhuis, Johannes D ; Skakkebæk, Niels E. ; Juul, Anders. / Increased basal and pulsatile secretion of FSH and LH in young men with 47,XXY or 46,XX karyotypes. In: European Journal of Endocrinology. 2008 ; Vol. 158, No. 6. pp. 803-810.
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AU - Aksglaede, Lise

AU - Jensen, Rikke Beck

AU - Carlsen, Elisabeth

AU - Kok, Petra

AU - Keenan, Daniel M.

AU - Veldhuis, Johannes D

AU - Skakkebæk, Niels E.

AU - Juul, Anders

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N2 - Objective: The regulation of normal sexual maturation and reproductive function is dependent on a precise hormonal regulation at hypothalamic, pituitary, and gonadal levels. The aim of this study was to investigate the neuroendocrine integrity of the pituitary-gonadal axis in patients with primary testicular failure due to supernumerary X chromosomes. Design: Cross-sectional study. Methods: In this study, 7 untreated patients with primary gonadal insufficiency due to SRY-positive 46,XX (n=4) and 46,XXY karyotypes (n=3) aged 18.8 years and 25 age-matched healthy controls participated. Reproductive hormones, testicular size, and overnight LH and FSH serum profiles and overnight urine LH and FSH excretion were determined. Results: Basal LH and FSH secretion was elevated 6.3- and 25.4-fold respectively in the patients and the amount of LH and FSH secreted per burst were 2.0- and 6.6-fold elevated. We found significantly more LH but not FSH peaks per 24 h, as estimated by the Weibull λ analysis. There was no difference between approximate entropy ratios or Weibull λ analyses indicating comparable orderliness and regularity of LH and FSH secretion. Overnight urinary LH and FSH excretion was significantly elevated in patients compared with controls and correlated significantly with calculated total overnight LH and FSH secretion respectively, thus validating deconvolution. Conclusion: In this group of patients with severe hypergonadotropic hypogonadism due to a supernumerary X chromosome, higher basal, pulsatile, and total LH and FSH secretion were associated with significantly more LH peaks per 24 h in comparison with healthy controls. Thus, our data indicate that in patients with Klinefelter syndrome and XX male karyotypes the entire hypothalamic-pituitary-gonadal axis has undergone functional changes.

AB - Objective: The regulation of normal sexual maturation and reproductive function is dependent on a precise hormonal regulation at hypothalamic, pituitary, and gonadal levels. The aim of this study was to investigate the neuroendocrine integrity of the pituitary-gonadal axis in patients with primary testicular failure due to supernumerary X chromosomes. Design: Cross-sectional study. Methods: In this study, 7 untreated patients with primary gonadal insufficiency due to SRY-positive 46,XX (n=4) and 46,XXY karyotypes (n=3) aged 18.8 years and 25 age-matched healthy controls participated. Reproductive hormones, testicular size, and overnight LH and FSH serum profiles and overnight urine LH and FSH excretion were determined. Results: Basal LH and FSH secretion was elevated 6.3- and 25.4-fold respectively in the patients and the amount of LH and FSH secreted per burst were 2.0- and 6.6-fold elevated. We found significantly more LH but not FSH peaks per 24 h, as estimated by the Weibull λ analysis. There was no difference between approximate entropy ratios or Weibull λ analyses indicating comparable orderliness and regularity of LH and FSH secretion. Overnight urinary LH and FSH excretion was significantly elevated in patients compared with controls and correlated significantly with calculated total overnight LH and FSH secretion respectively, thus validating deconvolution. Conclusion: In this group of patients with severe hypergonadotropic hypogonadism due to a supernumerary X chromosome, higher basal, pulsatile, and total LH and FSH secretion were associated with significantly more LH peaks per 24 h in comparison with healthy controls. Thus, our data indicate that in patients with Klinefelter syndrome and XX male karyotypes the entire hypothalamic-pituitary-gonadal axis has undergone functional changes.

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