TY - JOUR
T1 - Increased Ammoniagenesis as a Determinant of Progressive Renal Injury
AU - Nath, Karl A.
AU - Hostetter, Margaret K.
AU - Hostetter, Thomas H.
PY - 1991
Y1 - 1991
N2 - Loss of renal mass evokes increased ammoniagenesis in surviving nephrons, which in turn enables net acid excretion by the kidney. However, this compensatory increase in ammonia production in surviving nephrons triggers the alternative complement pathway, thereby instigating progressive tubulointerstitial injury. Ammonia has recently been identified as a stimulus to renal growth. Enhanced renal growth may serve as a forerunner for renal injury. The growth-promoting properties of ammonia may provide another mechanism through which augmented ammoniagenesis may underlie the enhancement of renal growth and injury observed in such models as the remnant kidney, hypokalemic nephropathy, high protein feeding, experimental diabetes nephropathy, and dietary deficiency of antioxidants.
AB - Loss of renal mass evokes increased ammoniagenesis in surviving nephrons, which in turn enables net acid excretion by the kidney. However, this compensatory increase in ammonia production in surviving nephrons triggers the alternative complement pathway, thereby instigating progressive tubulointerstitial injury. Ammonia has recently been identified as a stimulus to renal growth. Enhanced renal growth may serve as a forerunner for renal injury. The growth-promoting properties of ammonia may provide another mechanism through which augmented ammoniagenesis may underlie the enhancement of renal growth and injury observed in such models as the remnant kidney, hypokalemic nephropathy, high protein feeding, experimental diabetes nephropathy, and dietary deficiency of antioxidants.
KW - Ammonia
KW - growth
KW - oxidants
KW - tubulointerstitial injury
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U2 - 10.1016/S0272-6386(12)80344-1
DO - 10.1016/S0272-6386(12)80344-1
M3 - Article
C2 - 2042643
AN - SCOPUS:0025799751
SN - 0272-6386
VL - 17
SP - 654
EP - 657
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 6
ER -