Abstract
Celiac disease is an immune-mediated disorder triggered by hypersensitivity to gluten occurring in genetically susceptible individuals. A high-index of suspicion is needed for diagnosis as patients can be asymptomatic or present with atypical symptoms or extra-intestinal manifestations. Typical 18F-Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET)/Computed Tomography (CT) gastrointestinal manifestations of celiac disease include increased multifocal or diffuse jejunal and ileal uptake; focal duodenal uptake is less common. Splenomegaly with increased splenic FDG uptake is also uncommon in celiac disease in the absence of portal hypertension; small-sized spleen and functional hyposplenism are more typical. We report a case of celiac disease diagnosed after PET/CT showed FDG uptake in the duodenum and enlarged spleen. Follow-up after gluten-free diet showed complete metabolic resolution and regression of splenomegaly. The combination of focal bowel and splenic uptake is unusual in celiac disease and may be mistaken for a lymphoproliferative disorder. Awareness of this entity may avoid misdiagnosis and guide appropriate management.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 51-55 |
| Number of pages | 5 |
| Journal | Asia Oceania Journal of Nuclear Medicine and Biology |
| Volume | 9 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2021 |
Keywords
- 18F-FDG PET/CT
- Celiac disease
- Incidental bowel uptake
- Lymphoma
- Splenomegaly
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology (miscellaneous)
- Biophysics
- Radiology Nuclear Medicine and imaging
- Medicine (miscellaneous)