Incidental Lewy body disease: Electrophysiological findings suggesting pre-clinical Lewy body disorders

John N. Caviness, Charles H. Adler, Joseph G. Hentz, Holly A. Shill, Virgilio G.H. Evidente, Erika D. Driver-Dunckley, Marwan N. Sabbagh, Lucia Sue, Thomas G. Beach

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Objective: Evaluate electrophysiologic findings in incidental Lewy body disease (ILBD). Methods: ILBD, Control, and Parkinson's disease (PD) subjects had electrophysiological evaluation within 2. years prior to autopsy. Data analyzed included surface electromyography (EMG) of upper extremity muscles during rest and muscle activation, and electroencephalography (EEG) recording at rest. For EMG, gross tracings and spectral peaks were analyzed. EEG measures analyzed were background frequency and power in delta, theta, alpha, and beta bands. Results: Three of ten ILBD subjects (30%) showed unilateral rhythmic EMG discharges at rest without a visually apparent rest tremor. The ILBD resting EMG frequency was lower than in the Control group with no overlap (P=.03) and close to that of the PD group. The ILBD group had significantly lower background rhythm frequency than the Control group (P=.001) but was greater than the PD group (P=.01). Conclusions: The electrophysiologic changes in ILBD cases are between those of Control and PD, suggesting that these findings may reflect changes correlating with ILBD as a possible precursor to PD. Significance: Electrophysiologic changes in ILBD may assist with the identification of a preclinical stage for Lewy body disorders and help the development of a therapeutic agent for modifying Lewy body disease progression.

Original languageEnglish (US)
Pages (from-to)2426-2432
Number of pages7
JournalClinical Neurophysiology
Volume122
Issue number12
DOIs
StatePublished - Dec 2011

Keywords

  • Electroencephalography
  • Electromyography
  • Lewy body
  • Parkinson's disease
  • Pathology
  • Tremor

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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