Incidental lewy body disease: Clinical comparison to a control cohort

Charles H. Adler, Donald J. Connor, Joseph G. Hentz, Marwan N. Sabbagh, John N. Caviness, Holly A. Shill, Brie Noble, Thomas G. Beach

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

Limited clinical information has been published on cases pathologically diagnosed with incidental Lewy body disease (ILBD). Standardized, longitudinal movement and cognitive data was collected on a cohort of subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program. Of 277 autopsied subjects who had antemortem clinical evaluations within the previous 3 years, 76 did not have Parkinson's disease, a related disorder, or dementia of which 15 (20%) had ILBD. Minor extrapyramidal signs were common in subjects with and without ILBD. Cognitive testing revealed an abnormality in the ILBD group in the Trails B test only. ILBD cases had olfactory dysfunction; however, sample size was very small. This preliminary report revealed ILBD cases have movement and cognitive findings that for the most part were not out of proportion to similarly assessed and age-similar cases without Lewy bodies. Larger sample size is needed to have the power to better assess group differences.

Original languageEnglish (US)
Pages (from-to)642-646
Number of pages5
JournalMovement Disorders
Volume25
Issue number5
DOIs
StatePublished - Apr 15 2010

Keywords

  • Demential with lewy bodies
  • Incidental lewy body disease
  • Lewy bodies
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Adler, C. H., Connor, D. J., Hentz, J. G., Sabbagh, M. N., Caviness, J. N., Shill, H. A., Noble, B., & Beach, T. G. (2010). Incidental lewy body disease: Clinical comparison to a control cohort. Movement Disorders, 25(5), 642-646. https://doi.org/10.1002/mds.22971