Incident occurrence of depressive symptoms among patients with mild cognitive impairment - The Italian longitudinal study on aging

Vincenzo Solfrizzi, Alessia D'Introno, Anna M. Colacicco, Cristiano Capurso, Angelo Del Parigi, Richard John Caselli, Pier L. Scapicchio, Emanuele Scafato, Claudia Gandin, Antonio Capurso, Francesco Panza

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Aims: We estimated the prevalence and incidence rates of depressive symptoms and the role of vascular risk factors and sociodemographic variables on the occurrence of depressive symptoms in mild cognitive impairment (MCI). Methods: In the Italian Longitudinal Study on Aging, 2,963 individuals from 5,632 65- to 84-year-old subjects were evaluated at the 1st and 2nd survey, with a 3.5-year follow-up. Dementia and MCI were classified using current criteria. Depressive symptoms were measured with the Geriatric Depression Scale. Results: Among the 2,963 participants, 139 prevalent MCI cases were diagnosed with a depressive symptoms prevalence rate of 63.3%. During the 3.5-year follow-up, we estimated an incidence rate of depressive symptoms of 29.6 per 100 person-years. No sociodemographic variables or vascular risk factors modified the incidence of depressive symptoms in cognitively stable MCI patients or in MCI patients who reverted to normal cognition. Conclusion: In our population, there was a high prevalence and incidence of depressive symptoms in MCI. Our findings do not provide support for a possible role of vascular risk factors in the development of depressive symptoms in MCI, although these findings were based on relatively few cases of MCI, limiting the capacity to draw definitive conclusions.

Original languageEnglish (US)
Pages (from-to)55-64
Number of pages10
JournalDementia and Geriatric Cognitive Disorders
Volume24
Issue number1
DOIs
StatePublished - Jun 2007

Fingerprint

Longitudinal Studies
Depression
Incidence
Cognitive Dysfunction
Geriatrics
Cognition
Dementia
Population
vascular factor

Keywords

  • Depression
  • Mild cognitive impairment
  • Vascular risk factors in dementia

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

Cite this

Incident occurrence of depressive symptoms among patients with mild cognitive impairment - The Italian longitudinal study on aging. / Solfrizzi, Vincenzo; D'Introno, Alessia; Colacicco, Anna M.; Capurso, Cristiano; Del Parigi, Angelo; Caselli, Richard John; Scapicchio, Pier L.; Scafato, Emanuele; Gandin, Claudia; Capurso, Antonio; Panza, Francesco.

In: Dementia and Geriatric Cognitive Disorders, Vol. 24, No. 1, 06.2007, p. 55-64.

Research output: Contribution to journalArticle

Solfrizzi, V, D'Introno, A, Colacicco, AM, Capurso, C, Del Parigi, A, Caselli, RJ, Scapicchio, PL, Scafato, E, Gandin, C, Capurso, A & Panza, F 2007, 'Incident occurrence of depressive symptoms among patients with mild cognitive impairment - The Italian longitudinal study on aging', Dementia and Geriatric Cognitive Disorders, vol. 24, no. 1, pp. 55-64. https://doi.org/10.1159/000103632
Solfrizzi, Vincenzo ; D'Introno, Alessia ; Colacicco, Anna M. ; Capurso, Cristiano ; Del Parigi, Angelo ; Caselli, Richard John ; Scapicchio, Pier L. ; Scafato, Emanuele ; Gandin, Claudia ; Capurso, Antonio ; Panza, Francesco. / Incident occurrence of depressive symptoms among patients with mild cognitive impairment - The Italian longitudinal study on aging. In: Dementia and Geriatric Cognitive Disorders. 2007 ; Vol. 24, No. 1. pp. 55-64.
@article{3272ee28c2b74804aa03fcf86a6b06d4,
title = "Incident occurrence of depressive symptoms among patients with mild cognitive impairment - The Italian longitudinal study on aging",
abstract = "Aims: We estimated the prevalence and incidence rates of depressive symptoms and the role of vascular risk factors and sociodemographic variables on the occurrence of depressive symptoms in mild cognitive impairment (MCI). Methods: In the Italian Longitudinal Study on Aging, 2,963 individuals from 5,632 65- to 84-year-old subjects were evaluated at the 1st and 2nd survey, with a 3.5-year follow-up. Dementia and MCI were classified using current criteria. Depressive symptoms were measured with the Geriatric Depression Scale. Results: Among the 2,963 participants, 139 prevalent MCI cases were diagnosed with a depressive symptoms prevalence rate of 63.3{\%}. During the 3.5-year follow-up, we estimated an incidence rate of depressive symptoms of 29.6 per 100 person-years. No sociodemographic variables or vascular risk factors modified the incidence of depressive symptoms in cognitively stable MCI patients or in MCI patients who reverted to normal cognition. Conclusion: In our population, there was a high prevalence and incidence of depressive symptoms in MCI. Our findings do not provide support for a possible role of vascular risk factors in the development of depressive symptoms in MCI, although these findings were based on relatively few cases of MCI, limiting the capacity to draw definitive conclusions.",
keywords = "Depression, Mild cognitive impairment, Vascular risk factors in dementia",
author = "Vincenzo Solfrizzi and Alessia D'Introno and Colacicco, {Anna M.} and Cristiano Capurso and {Del Parigi}, Angelo and Caselli, {Richard John} and Scapicchio, {Pier L.} and Emanuele Scafato and Claudia Gandin and Antonio Capurso and Francesco Panza",
year = "2007",
month = "6",
doi = "10.1159/000103632",
language = "English (US)",
volume = "24",
pages = "55--64",
journal = "Dementia and Geriatric Cognitive Disorders",
issn = "1420-8008",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Incident occurrence of depressive symptoms among patients with mild cognitive impairment - The Italian longitudinal study on aging

AU - Solfrizzi, Vincenzo

AU - D'Introno, Alessia

AU - Colacicco, Anna M.

AU - Capurso, Cristiano

AU - Del Parigi, Angelo

AU - Caselli, Richard John

AU - Scapicchio, Pier L.

AU - Scafato, Emanuele

AU - Gandin, Claudia

AU - Capurso, Antonio

AU - Panza, Francesco

PY - 2007/6

Y1 - 2007/6

N2 - Aims: We estimated the prevalence and incidence rates of depressive symptoms and the role of vascular risk factors and sociodemographic variables on the occurrence of depressive symptoms in mild cognitive impairment (MCI). Methods: In the Italian Longitudinal Study on Aging, 2,963 individuals from 5,632 65- to 84-year-old subjects were evaluated at the 1st and 2nd survey, with a 3.5-year follow-up. Dementia and MCI were classified using current criteria. Depressive symptoms were measured with the Geriatric Depression Scale. Results: Among the 2,963 participants, 139 prevalent MCI cases were diagnosed with a depressive symptoms prevalence rate of 63.3%. During the 3.5-year follow-up, we estimated an incidence rate of depressive symptoms of 29.6 per 100 person-years. No sociodemographic variables or vascular risk factors modified the incidence of depressive symptoms in cognitively stable MCI patients or in MCI patients who reverted to normal cognition. Conclusion: In our population, there was a high prevalence and incidence of depressive symptoms in MCI. Our findings do not provide support for a possible role of vascular risk factors in the development of depressive symptoms in MCI, although these findings were based on relatively few cases of MCI, limiting the capacity to draw definitive conclusions.

AB - Aims: We estimated the prevalence and incidence rates of depressive symptoms and the role of vascular risk factors and sociodemographic variables on the occurrence of depressive symptoms in mild cognitive impairment (MCI). Methods: In the Italian Longitudinal Study on Aging, 2,963 individuals from 5,632 65- to 84-year-old subjects were evaluated at the 1st and 2nd survey, with a 3.5-year follow-up. Dementia and MCI were classified using current criteria. Depressive symptoms were measured with the Geriatric Depression Scale. Results: Among the 2,963 participants, 139 prevalent MCI cases were diagnosed with a depressive symptoms prevalence rate of 63.3%. During the 3.5-year follow-up, we estimated an incidence rate of depressive symptoms of 29.6 per 100 person-years. No sociodemographic variables or vascular risk factors modified the incidence of depressive symptoms in cognitively stable MCI patients or in MCI patients who reverted to normal cognition. Conclusion: In our population, there was a high prevalence and incidence of depressive symptoms in MCI. Our findings do not provide support for a possible role of vascular risk factors in the development of depressive symptoms in MCI, although these findings were based on relatively few cases of MCI, limiting the capacity to draw definitive conclusions.

KW - Depression

KW - Mild cognitive impairment

KW - Vascular risk factors in dementia

UR - http://www.scopus.com/inward/record.url?scp=34250845862&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250845862&partnerID=8YFLogxK

U2 - 10.1159/000103632

DO - 10.1159/000103632

M3 - Article

C2 - 17565214

AN - SCOPUS:34250845862

VL - 24

SP - 55

EP - 64

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

SN - 1420-8008

IS - 1

ER -