Abstract
Chimeric antigen receptor (CAR) T-cell therapy is effective in relapsed/refractory large B-cell lymphoma and results in a unique toxicity profile, namely cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome. The hyper-inflammatory state associated with these toxicities has been suggested to increase the risk of thrombosis. We conducted a retrospective analysis of patients treated with axicabtagene ciloleucel (axi-cel) to assess the rate of thrombosis with axi-cel therapy from the time of CAR T-cell infusion until the end of hospitalization, when performed in the inpatient setting, or up to day +30 when performed in the outpatient setting. Ninety-two (95%) of 97 patients were hospitalized during axi-cel therapy and 85 (88%) developed CRS. Fifty-five patients (57%) received concurrent anticoagulation (53 as prophylaxis). Patients with prior VTE did not have progression or evidence of new VTE. Only 2 (2.1%) patients developed VTE. These results demonstrate a low-risk for thrombosis in axi-cel recipients.
Original language | English (US) |
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Pages (from-to) | 1363-1368 |
Number of pages | 6 |
Journal | Leukemia and Lymphoma |
Volume | 63 |
Issue number | 6 |
DOIs | |
State | Published - 2022 |
Keywords
- CAR T-cell
- coagulopathy
- cytokine release syndrome
- lymphoma
- thrombosis
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research