Incidence of Supraventricular Arrhythmias during Autologous peripheral blood stem cell transplantation

Abhishek Singla, William Hogan, Stephen Maxted Ansell, Francis K. Buadi, David M Dingli, Angela Dispenzieri, Dennis A. Gastineau, Morie Gertz, Suzanne R. Hayman, David J. Inwards, Patrick Bruce Johnston, Martha Lacy, Mark R Litzow, Ivana Micallef, Luis F. Porrata, Shaji K Kumar

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11 Citations (Scopus)

Abstract

Arrhythmias, especially supraventricular arrhythmias, often complicate the clinical course during autologous hematopoietic cell transplantation (AHCT). We wanted to determine the incidence and risk factors for cardiac arrhythmias during AHCT. The study included 983 patients (median age, 58 years [range, 19 to 77]; 61% male) who underwent AHCT between August 2006 and December 2010 at a single institution and for whom all relevant medical records were available for review. AHCT was done for plasma cell disorders in 58% patients and for lymphoma or leukemia in the remaining. Overall, 92 patients (9.4%) developed a supraventricular tachyarrhythmia at a median of 9 days posttransplantation (range, 0 to 18) and with a median duration of less than 1 day (range, <1 to 17 days). Atrial fibrillation was the most common and seen in 71 patients (7%), followed by atrial flutter and supraventricular tachycardia in 12 (1%) and 8 (1%) patients, respectively. In multivariate analysis, age older than 63 years, presence of premature supraventricular complexes or atrioventricular conduction delay on pretransplantation electrocardiogram, and history of any prior arrhythmia increased the risk of arrhythmia. Development of arrhythmia resulted in longer outpatient follow-up after AHCT, with the median follow-up for those developing an arrhythmia of 22 days compared with 19 days for the rest; P < .001. In conclusion, 9% of patients undergoing ASCT developed supraventricular arrhythmias posttransplantation, and this risk was elevated among older patients, those with a prior history of arrhythmias, and those with pretransplantation electrocardiographic abnormalities.

Original languageEnglish (US)
Pages (from-to)1233-1237
Number of pages5
JournalBiology of Blood and Marrow Transplantation
Volume19
Issue number8
DOIs
StatePublished - Aug 2013

Fingerprint

Peripheral Blood Stem Cell Transplantation
Cardiac Arrhythmias
Cell Transplantation
Incidence
Atrial Flutter
Supraventricular Tachycardia
Plasma Cells
Tachycardia
Atrial Fibrillation
Medical Records
Lymphoma
Electrocardiography
Leukemia
Outpatients
Multivariate Analysis

Keywords

  • Antiarrhythmics
  • Arrhythmia
  • Atrial fibrillation
  • Autologous hematopoietic cell transplant (AHCT)
  • Electrocardiogram (ECG)

ASJC Scopus subject areas

  • Transplantation
  • Hematology

Cite this

@article{648ed4d80feb4384bf50c237df462a83,
title = "Incidence of Supraventricular Arrhythmias during Autologous peripheral blood stem cell transplantation",
abstract = "Arrhythmias, especially supraventricular arrhythmias, often complicate the clinical course during autologous hematopoietic cell transplantation (AHCT). We wanted to determine the incidence and risk factors for cardiac arrhythmias during AHCT. The study included 983 patients (median age, 58 years [range, 19 to 77]; 61{\%} male) who underwent AHCT between August 2006 and December 2010 at a single institution and for whom all relevant medical records were available for review. AHCT was done for plasma cell disorders in 58{\%} patients and for lymphoma or leukemia in the remaining. Overall, 92 patients (9.4{\%}) developed a supraventricular tachyarrhythmia at a median of 9 days posttransplantation (range, 0 to 18) and with a median duration of less than 1 day (range, <1 to 17 days). Atrial fibrillation was the most common and seen in 71 patients (7{\%}), followed by atrial flutter and supraventricular tachycardia in 12 (1{\%}) and 8 (1{\%}) patients, respectively. In multivariate analysis, age older than 63 years, presence of premature supraventricular complexes or atrioventricular conduction delay on pretransplantation electrocardiogram, and history of any prior arrhythmia increased the risk of arrhythmia. Development of arrhythmia resulted in longer outpatient follow-up after AHCT, with the median follow-up for those developing an arrhythmia of 22 days compared with 19 days for the rest; P < .001. In conclusion, 9{\%} of patients undergoing ASCT developed supraventricular arrhythmias posttransplantation, and this risk was elevated among older patients, those with a prior history of arrhythmias, and those with pretransplantation electrocardiographic abnormalities.",
keywords = "Antiarrhythmics, Arrhythmia, Atrial fibrillation, Autologous hematopoietic cell transplant (AHCT), Electrocardiogram (ECG)",
author = "Abhishek Singla and William Hogan and Ansell, {Stephen Maxted} and Buadi, {Francis K.} and Dingli, {David M} and Angela Dispenzieri and Gastineau, {Dennis A.} and Morie Gertz and Hayman, {Suzanne R.} and Inwards, {David J.} and Johnston, {Patrick Bruce} and Martha Lacy and Litzow, {Mark R} and Ivana Micallef and Porrata, {Luis F.} and Kumar, {Shaji K}",
year = "2013",
month = "8",
doi = "10.1016/j.bbmt.2013.05.019",
language = "English (US)",
volume = "19",
pages = "1233--1237",
journal = "Biology of Blood and Marrow Transplantation",
issn = "1083-8791",
publisher = "Elsevier Inc.",
number = "8",

}

TY - JOUR

T1 - Incidence of Supraventricular Arrhythmias during Autologous peripheral blood stem cell transplantation

AU - Singla, Abhishek

AU - Hogan, William

AU - Ansell, Stephen Maxted

AU - Buadi, Francis K.

AU - Dingli, David M

AU - Dispenzieri, Angela

AU - Gastineau, Dennis A.

AU - Gertz, Morie

AU - Hayman, Suzanne R.

AU - Inwards, David J.

AU - Johnston, Patrick Bruce

AU - Lacy, Martha

AU - Litzow, Mark R

AU - Micallef, Ivana

AU - Porrata, Luis F.

AU - Kumar, Shaji K

PY - 2013/8

Y1 - 2013/8

N2 - Arrhythmias, especially supraventricular arrhythmias, often complicate the clinical course during autologous hematopoietic cell transplantation (AHCT). We wanted to determine the incidence and risk factors for cardiac arrhythmias during AHCT. The study included 983 patients (median age, 58 years [range, 19 to 77]; 61% male) who underwent AHCT between August 2006 and December 2010 at a single institution and for whom all relevant medical records were available for review. AHCT was done for plasma cell disorders in 58% patients and for lymphoma or leukemia in the remaining. Overall, 92 patients (9.4%) developed a supraventricular tachyarrhythmia at a median of 9 days posttransplantation (range, 0 to 18) and with a median duration of less than 1 day (range, <1 to 17 days). Atrial fibrillation was the most common and seen in 71 patients (7%), followed by atrial flutter and supraventricular tachycardia in 12 (1%) and 8 (1%) patients, respectively. In multivariate analysis, age older than 63 years, presence of premature supraventricular complexes or atrioventricular conduction delay on pretransplantation electrocardiogram, and history of any prior arrhythmia increased the risk of arrhythmia. Development of arrhythmia resulted in longer outpatient follow-up after AHCT, with the median follow-up for those developing an arrhythmia of 22 days compared with 19 days for the rest; P < .001. In conclusion, 9% of patients undergoing ASCT developed supraventricular arrhythmias posttransplantation, and this risk was elevated among older patients, those with a prior history of arrhythmias, and those with pretransplantation electrocardiographic abnormalities.

AB - Arrhythmias, especially supraventricular arrhythmias, often complicate the clinical course during autologous hematopoietic cell transplantation (AHCT). We wanted to determine the incidence and risk factors for cardiac arrhythmias during AHCT. The study included 983 patients (median age, 58 years [range, 19 to 77]; 61% male) who underwent AHCT between August 2006 and December 2010 at a single institution and for whom all relevant medical records were available for review. AHCT was done for plasma cell disorders in 58% patients and for lymphoma or leukemia in the remaining. Overall, 92 patients (9.4%) developed a supraventricular tachyarrhythmia at a median of 9 days posttransplantation (range, 0 to 18) and with a median duration of less than 1 day (range, <1 to 17 days). Atrial fibrillation was the most common and seen in 71 patients (7%), followed by atrial flutter and supraventricular tachycardia in 12 (1%) and 8 (1%) patients, respectively. In multivariate analysis, age older than 63 years, presence of premature supraventricular complexes or atrioventricular conduction delay on pretransplantation electrocardiogram, and history of any prior arrhythmia increased the risk of arrhythmia. Development of arrhythmia resulted in longer outpatient follow-up after AHCT, with the median follow-up for those developing an arrhythmia of 22 days compared with 19 days for the rest; P < .001. In conclusion, 9% of patients undergoing ASCT developed supraventricular arrhythmias posttransplantation, and this risk was elevated among older patients, those with a prior history of arrhythmias, and those with pretransplantation electrocardiographic abnormalities.

KW - Antiarrhythmics

KW - Arrhythmia

KW - Atrial fibrillation

KW - Autologous hematopoietic cell transplant (AHCT)

KW - Electrocardiogram (ECG)

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JF - Biology of Blood and Marrow Transplantation

SN - 1083-8791

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