TY - JOUR
T1 - Incidence of pediatric Horner syndrome and the risk of neuroblastoma
T2 - A population-based study
AU - Smith, Stephen J.
AU - Diehl, Nancy
AU - Leavitt, Jacqueline A.
AU - Mohney, Brian G.
PY - 2010/3
Y1 - 2010/3
N2 - Objective: To describe the incidence of pediatric Horner syndrome and the risk of occult malignancy in a population-based cohort. Methods: The medical records of all pediatric patients (aged <19 years) residing in Olmsted County, Minnesota, who received diagnoses of Horner syndrome from January 1, 1969, through December 31, 2008, were retrospectively reviewed. Results: Horner syndrome was diagnosed in 20 pediatric patients during the 40-year period, yielding an age-and sex-adjusted incidence of 1.42 per 100 000 patients younger than 19 years of age (95% confidence interval [CI], 0.80-2.04). Eleven of the 20 patients (55%) had a congenital onset, for a birth prevalence of 1 in 6250 (95% CI, 3333-10 000), while the remaining 9 (45%) had acquired syndromes. Seven of the 11 (63.6%) patients with congenital cases had a history of birth trauma, while the remaining 4 (36.4%) had no identifiable cause. Six of the 9 (66%) acquired cases occurred following surgery or trauma, while the remaining 3 (33%) had no known etiology. None of the 20 patients (95% CI, 0.0%-16.8%) were found to have a neuroblastoma or other malignancy during a mean follow-up of 56.5 months (range, 0-256.9 months). Conclusions: The incidence of pediatric Horner syndrome in this population was 1.42 per 100000 patients younger than 19 years, with a birth prevalence of 1 in 6250 for those with a congenital onset. Birth, surgical, or other trauma occurred in 13 (65%) of the patients, while none were found to have an underlying mass lesion, suggesting a need for reappraising current recommendations for extensive evaluations in these patients.
AB - Objective: To describe the incidence of pediatric Horner syndrome and the risk of occult malignancy in a population-based cohort. Methods: The medical records of all pediatric patients (aged <19 years) residing in Olmsted County, Minnesota, who received diagnoses of Horner syndrome from January 1, 1969, through December 31, 2008, were retrospectively reviewed. Results: Horner syndrome was diagnosed in 20 pediatric patients during the 40-year period, yielding an age-and sex-adjusted incidence of 1.42 per 100 000 patients younger than 19 years of age (95% confidence interval [CI], 0.80-2.04). Eleven of the 20 patients (55%) had a congenital onset, for a birth prevalence of 1 in 6250 (95% CI, 3333-10 000), while the remaining 9 (45%) had acquired syndromes. Seven of the 11 (63.6%) patients with congenital cases had a history of birth trauma, while the remaining 4 (36.4%) had no identifiable cause. Six of the 9 (66%) acquired cases occurred following surgery or trauma, while the remaining 3 (33%) had no known etiology. None of the 20 patients (95% CI, 0.0%-16.8%) were found to have a neuroblastoma or other malignancy during a mean follow-up of 56.5 months (range, 0-256.9 months). Conclusions: The incidence of pediatric Horner syndrome in this population was 1.42 per 100000 patients younger than 19 years, with a birth prevalence of 1 in 6250 for those with a congenital onset. Birth, surgical, or other trauma occurred in 13 (65%) of the patients, while none were found to have an underlying mass lesion, suggesting a need for reappraising current recommendations for extensive evaluations in these patients.
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U2 - 10.1001/archophthalmol.2010.6
DO - 10.1001/archophthalmol.2010.6
M3 - Article
C2 - 20212203
AN - SCOPUS:77749307470
SN - 0003-9950
VL - 128
SP - 324
EP - 329
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 3
ER -