Incidence of hip fractures in osteoporotic women treated with sodium fluoride.

B. L. Riggs, D. J. Baylink, M. Kleerekoper, J. M. Lane, L. J. Melton, P. J. Meunier

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

It has been suggested recently that, although fluoride therapy may decrease the occurrence of vertebral fractures, it could increase the risk of hip fractures. To evaluate this possibility, we combined retrospective data from five medical centers that have had a large experience with this therapeutic regimen. In 416 osteoporotic patients who were followed for more than 1,000 patient-years of fluoride treatment, there were 17 nontraumatic hip fractures. This incidence of 1.6% per year is similar to the incidence, 1.9% per year, for 120 of the patients in this series who had been followed prospectively for 3 years prior to initiation of fluoride therapy. The expected incidence for women of the same age in the general community is 0.5% per year. Thus, untreated osteoporotic women are at increased risk for hip fracture, but treatment with fluoride seems neither to decrease nor to increase the incidence of hip fracture substantially.

Original languageEnglish (US)
Pages (from-to)123-126
Number of pages4
JournalJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume2
Issue number2
StatePublished - Apr 1987

ASJC Scopus subject areas

  • Surgery

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