Incidence of frontotemporal disorders in Olmsted County: A population-based study

Pierpaolo Turcano; Cole D. Stang; Michelle M. Mielke; Peter R. Martin; Sudhindra G. Upadhyaya; Keith A. Josephs; Bradley F. Boeve; David S. Knopman; Ronald C. Petersen; Rodolfo Savica

doi:10.1016/j.jalz.2019.08.199

Incidence of frontotemporal disorders in Olmsted County: A population-based study

Pierpaolo Turcano, Cole D. Stang, Michelle M. Mielke, Peter R. Martin, Sudhindra G. Upadhyaya, Keith A. Josephs, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Rodolfo Savica

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3 Scopus citations

Abstract

Introduction: Frontotemporal dementia disorders (FTDs) are heterogeneous phenotypical behavioral and language disorders usually associated with frontal and/or temporal lobe degeneration. We investigated their incidence in a population-based cohort. Methods: Using a records-linkage system, we identified all patients with a diagnostic code for dementia in Olmsted County, MN, 1995–2010, and confirmed the diagnosis of FTD. A behavioral neurologist verified the clinical diagnosis and determined phenotypes. Results: We identified 35 FTDs cases. Overall, the incidence of FTDs was 4.3/100,000/year (95% CI: 2.9, 5.7). Incidence was higher in men (6.3/100,000, 95% CI 3.6, 9.0) than women (2.9/100,000; 95% CI: 1.3, 4.5); we observed an increased trend over time (B = 0.83, 95% CI: 0.54, 1.11, P <.001). At autopsy, clinical diagnosis was confirmed in eight (72.7%) cases. Discussion: We observed an increased incidence and trends of FTDs over time. This may reflect a better recognition by clinicians and improvement of clinical criteria and diagnostic tools.

Original language	English (US)
Pages (from-to)	482-490
Number of pages	9
Journal	Alzheimer's and Dementia
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.jalz.2019.08.199
State	Published - Mar 1 2020

Keywords

Behavioral variant frontotemporal dementia
Frontotemporal-dementia disorders (FTDs)
Incidence
Neurodegenerative dementia
Population-based cohort

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1016/j.jalz.2019.08.199

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title = "Incidence of frontotemporal disorders in Olmsted County: A population-based study",

abstract = "Introduction: Frontotemporal dementia disorders (FTDs) are heterogeneous phenotypical behavioral and language disorders usually associated with frontal and/or temporal lobe degeneration. We investigated their incidence in a population-based cohort. Methods: Using a records-linkage system, we identified all patients with a diagnostic code for dementia in Olmsted County, MN, 1995–2010, and confirmed the diagnosis of FTD. A behavioral neurologist verified the clinical diagnosis and determined phenotypes. Results: We identified 35 FTDs cases. Overall, the incidence of FTDs was 4.3/100,000/year (95% CI: 2.9, 5.7). Incidence was higher in men (6.3/100,000, 95% CI 3.6, 9.0) than women (2.9/100,000; 95% CI: 1.3, 4.5); we observed an increased trend over time (B = 0.83, 95% CI: 0.54, 1.11, P <.001). At autopsy, clinical diagnosis was confirmed in eight (72.7%) cases. Discussion: We observed an increased incidence and trends of FTDs over time. This may reflect a better recognition by clinicians and improvement of clinical criteria and diagnostic tools.",

keywords = "Behavioral variant frontotemporal dementia, Frontotemporal-dementia disorders (FTDs), Incidence, Neurodegenerative dementia, Population-based cohort",

author = "Pierpaolo Turcano and Stang, {Cole D.} and Mielke, {Michelle M.} and Martin, {Peter R.} and Upadhyaya, {Sudhindra G.} and Josephs, {Keith A.} and Boeve, {Bradley F.} and Knopman, {David S.} and Petersen, {Ronald C.} and Rodolfo Savica",

note = "Publisher Copyright: {\textcopyright} 2019 the Alzheimer's Association",

year = "2020",

month = mar,

day = "1",

doi = "10.1016/j.jalz.2019.08.199",

language = "English (US)",

volume = "16",

pages = "482--490",

journal = "Alzheimer's and Dementia",

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T1 - Incidence of frontotemporal disorders in Olmsted County

T2 - A population-based study

AU - Turcano, Pierpaolo

AU - Stang, Cole D.

AU - Mielke, Michelle M.

AU - Martin, Peter R.

AU - Upadhyaya, Sudhindra G.

AU - Josephs, Keith A.

AU - Boeve, Bradley F.

AU - Knopman, David S.

AU - Petersen, Ronald C.

AU - Savica, Rodolfo

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Introduction: Frontotemporal dementia disorders (FTDs) are heterogeneous phenotypical behavioral and language disorders usually associated with frontal and/or temporal lobe degeneration. We investigated their incidence in a population-based cohort. Methods: Using a records-linkage system, we identified all patients with a diagnostic code for dementia in Olmsted County, MN, 1995–2010, and confirmed the diagnosis of FTD. A behavioral neurologist verified the clinical diagnosis and determined phenotypes. Results: We identified 35 FTDs cases. Overall, the incidence of FTDs was 4.3/100,000/year (95% CI: 2.9, 5.7). Incidence was higher in men (6.3/100,000, 95% CI 3.6, 9.0) than women (2.9/100,000; 95% CI: 1.3, 4.5); we observed an increased trend over time (B = 0.83, 95% CI: 0.54, 1.11, P <.001). At autopsy, clinical diagnosis was confirmed in eight (72.7%) cases. Discussion: We observed an increased incidence and trends of FTDs over time. This may reflect a better recognition by clinicians and improvement of clinical criteria and diagnostic tools.

AB - Introduction: Frontotemporal dementia disorders (FTDs) are heterogeneous phenotypical behavioral and language disorders usually associated with frontal and/or temporal lobe degeneration. We investigated their incidence in a population-based cohort. Methods: Using a records-linkage system, we identified all patients with a diagnostic code for dementia in Olmsted County, MN, 1995–2010, and confirmed the diagnosis of FTD. A behavioral neurologist verified the clinical diagnosis and determined phenotypes. Results: We identified 35 FTDs cases. Overall, the incidence of FTDs was 4.3/100,000/year (95% CI: 2.9, 5.7). Incidence was higher in men (6.3/100,000, 95% CI 3.6, 9.0) than women (2.9/100,000; 95% CI: 1.3, 4.5); we observed an increased trend over time (B = 0.83, 95% CI: 0.54, 1.11, P <.001). At autopsy, clinical diagnosis was confirmed in eight (72.7%) cases. Discussion: We observed an increased incidence and trends of FTDs over time. This may reflect a better recognition by clinicians and improvement of clinical criteria and diagnostic tools.

KW - Behavioral variant frontotemporal dementia

KW - Frontotemporal-dementia disorders (FTDs)

KW - Incidence

KW - Neurodegenerative dementia

KW - Population-based cohort

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Incidence of frontotemporal disorders in Olmsted County: A population-based study

Abstract

Keywords

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