Incidence of frontotemporal disorders in Olmsted County: A population-based study

Pierpaolo Turcano; Cole D. Stang; Michelle M. Mielke; Peter R. Martin; Sudhindra G. Upadhyaya; Keith A. Josephs; Bradley F. Boeve; David S. Knopman; Ronald C. Petersen; Rodolfo Savica

doi:10.1016/j.jalz.2019.08.199

Incidence of frontotemporal disorders in Olmsted County: A population-based study

Pierpaolo Turcano, Cole D. Stang, Michelle M. Mielke, Peter R. Martin, Sudhindra G. Upadhyaya, Keith A. Josephs, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Rodolfo Savica

Research output: Contribution to journal › Article

Abstract

Introduction: Frontotemporal dementia disorders (FTDs) are heterogeneous phenotypical behavioral and language disorders usually associated with frontal and/or temporal lobe degeneration. We investigated their incidence in a population-based cohort. Methods: Using a records-linkage system, we identified all patients with a diagnostic code for dementia in Olmsted County, MN, 1995–2010, and confirmed the diagnosis of FTD. A behavioral neurologist verified the clinical diagnosis and determined phenotypes. Results: We identified 35 FTDs cases. Overall, the incidence of FTDs was 4.3/100,000/year (95% CI: 2.9, 5.7). Incidence was higher in men (6.3/100,000, 95% CI 3.6, 9.0) than women (2.9/100,000; 95% CI: 1.3, 4.5); we observed an increased trend over time (B = 0.83, 95% CI: 0.54, 1.11, P < .001). At autopsy, clinical diagnosis was confirmed in eight (72.7%) cases. Discussion: We observed an increased incidence and trends of FTDs over time. This may reflect a better recognition by clinicians and improvement of clinical criteria and diagnostic tools.

Original language	English (US)
Journal	Alzheimer's and Dementia
DOIs	https://doi.org/10.1016/j.jalz.2019.08.199
State	Accepted/In press - Jan 1 2019

Keywords

Behavioral variant frontotemporal dementia
Frontotemporal-dementia disorders (FTDs)
Incidence
Neurodegenerative dementia
Population-based cohort

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience

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Turcano, P., Stang, C. D., Mielke, M. M., Martin, P. R., Upadhyaya, S. G., Josephs, K. A., Boeve, B. F., Knopman, D. S., Petersen, R. C., & Savica, R. (Accepted/In press). Incidence of frontotemporal disorders in Olmsted County: A population-based study. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2019.08.199

Incidence of frontotemporal disorders in Olmsted County : A population-based study. / Turcano, Pierpaolo; Stang, Cole D.; Mielke, Michelle M.; Martin, Peter R.; Upadhyaya, Sudhindra G.; Josephs, Keith A.; Boeve, Bradley F.; Knopman, David S.; Petersen, Ronald C.; Savica, Rodolfo.

In: Alzheimer's and Dementia, 01.01.2019.

Research output: Contribution to journal › Article

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abstract = "Introduction: Frontotemporal dementia disorders (FTDs) are heterogeneous phenotypical behavioral and language disorders usually associated with frontal and/or temporal lobe degeneration. We investigated their incidence in a population-based cohort. Methods: Using a records-linkage system, we identified all patients with a diagnostic code for dementia in Olmsted County, MN, 1995–2010, and confirmed the diagnosis of FTD. A behavioral neurologist verified the clinical diagnosis and determined phenotypes. Results: We identified 35 FTDs cases. Overall, the incidence of FTDs was 4.3/100,000/year (95% CI: 2.9, 5.7). Incidence was higher in men (6.3/100,000, 95% CI 3.6, 9.0) than women (2.9/100,000; 95% CI: 1.3, 4.5); we observed an increased trend over time (B = 0.83, 95% CI: 0.54, 1.11, P < .001). At autopsy, clinical diagnosis was confirmed in eight (72.7%) cases. Discussion: We observed an increased incidence and trends of FTDs over time. This may reflect a better recognition by clinicians and improvement of clinical criteria and diagnostic tools.",

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