Incidence of frontotemporal disorders in Olmsted County: A population-based study

Pierpaolo Turcano, Cole D. Stang, Michelle M. Mielke, Peter R. Martin, Sudhindra G. Upadhyaya, Keith A. Josephs, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Rodolfo Savica

Research output: Contribution to journalArticle

Abstract

Introduction: Frontotemporal dementia disorders (FTDs) are heterogeneous phenotypical behavioral and language disorders usually associated with frontal and/or temporal lobe degeneration. We investigated their incidence in a population-based cohort. Methods: Using a records-linkage system, we identified all patients with a diagnostic code for dementia in Olmsted County, MN, 1995–2010, and confirmed the diagnosis of FTD. A behavioral neurologist verified the clinical diagnosis and determined phenotypes. Results: We identified 35 FTDs cases. Overall, the incidence of FTDs was 4.3/100,000/year (95% CI: 2.9, 5.7). Incidence was higher in men (6.3/100,000, 95% CI 3.6, 9.0) than women (2.9/100,000; 95% CI: 1.3, 4.5); we observed an increased trend over time (B = 0.83, 95% CI: 0.54, 1.11, P < .001). At autopsy, clinical diagnosis was confirmed in eight (72.7%) cases. Discussion: We observed an increased incidence and trends of FTDs over time. This may reflect a better recognition by clinicians and improvement of clinical criteria and diagnostic tools.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Frontotemporal Dementia
Incidence
Population
Language Disorders
Frontal Lobe
Temporal Lobe
Dementia
Autopsy
Phenotype

Keywords

  • Behavioral variant frontotemporal dementia
  • Frontotemporal-dementia disorders (FTDs)
  • Incidence
  • Neurodegenerative dementia
  • Population-based cohort

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Incidence of frontotemporal disorders in Olmsted County : A population-based study. / Turcano, Pierpaolo; Stang, Cole D.; Mielke, Michelle M.; Martin, Peter R.; Upadhyaya, Sudhindra G.; Josephs, Keith A.; Boeve, Bradley F.; Knopman, David S.; Petersen, Ronald C.; Savica, Rodolfo.

In: Alzheimer's and Dementia, 01.01.2019.

Research output: Contribution to journalArticle

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AU - Martin, Peter R.

AU - Upadhyaya, Sudhindra G.

AU - Josephs, Keith A.

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