Incidence of extramedullary disease in patients with multiple myeloma in the era of novel therapy, and the activity of pomalidomide on extramedullary myeloma

K. D. Short, S. V. Rajkumar, D. Larson, F. Buadi, S. Hayman, A. Dispenzieri, M. Gertz, S. Kumar, J. Mikhael, V. Roy, R. A. Kyle, M. Q. Lacy

Research output: Contribution to journalReview article

98 Scopus citations

Abstract

We studied 174 consecutive patients with relapsed refractory multiple myeloma (MM) enrolled on a phase II clinical trial of pomalidomide plus low-dose dexamethasone at Mayo Clinic. Extramedullary disease (EMD) was present at the time of trial entry in 7.5% (13 of 174 patients). The rate of EMD in the first 3 years following diagnosis of MM was 3%. The response of EMD to pomalidomide plus low-dose dexamethasone included two complete and two partial responses among the 13 patients (response rate, 31%). Overall survival measured from trial entry was significantly shorter for patients with treatment-emergent EMD compared with those who did not have EMD, (median 16 months versus not reached, P0.002).

Original languageEnglish (US)
Pages (from-to)906-908
Number of pages3
JournalLeukemia
Volume25
Issue number6
DOIs
StatePublished - Jun 2011

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Keywords

  • extramedullary
  • myeloma
  • pomalidomide

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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