Incidence of dementia among participants and nonparticipants in a longitudinal study of cognitive aging

David S Knopman, Rosebud O Roberts, V. Shane Pankratz, Ruth H. Cha, Walter A Rocca, Michelle M Mielke, Bradley F Boeve, Eric George Tangalos, Robert J. Ivnik, Yonas Endale Geda, Ronald Carl Petersen

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13 Citations (Scopus)

Abstract

Although rates of incident dementia have been reported from several populations, the impact of nonparticipation on dementia incidence in studies of cognitive aging is unknown. In 2004, investigators with the Mayo Clinic Study of Aging selected persons aged 70-89 years from an enumeration of all Olmsted County, Minnesota, residents (ageand sex-stratified random sample). Of 4,398 potential participants, 2,050 agreed to undergo an in-person health assessment. Those participants were reevaluated in person using standard diagnostic procedures approximately every 15 months over a median follow-up period of 5.7 years (through September 15, 2013). There were 1,679 persons who refused any participation. A trained nurse abstractor reviewed the medical records of nonparticipants using the Rochester Epidemiology Project's medical record linkage system a median of 3.9 years after refusal. Nonparticipants had a higher prevalence of dementia than participants evaluated in person (6.5% vs. 3.3%;P<0.0001). The standardized incidence of dementia was not significantly higher among the nonparticipants (23.2 per 1,000 person-years) than in those evaluated in person (19.6 per 1,000 person-years; hazard ratio = 1.17, 95% confidence interval: 0.95, 1.43 (P =0.13); adjusted for education and sex, with age as the time scale). The small, nonsignificant impact of nonparticipation on rates of incident dementia is reassuring for future studies based on incident dementia cases.

Original languageEnglish (US)
Pages (from-to)414-423
Number of pages10
JournalAmerican Journal of Epidemiology
Volume180
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Longitudinal Studies
Dementia
Incidence
Medical Record Linkage
Sex Education
Cognitive Aging
Medical Records
Epidemiology
Cohort Studies
Nurses
Research Personnel
Confidence Intervals
Health
Population

Keywords

  • Aging
  • Cognition
  • Cognitive aging
  • Dementia
  • Epidemiologic methods
  • Incidence
  • Prevalence

ASJC Scopus subject areas

  • Epidemiology

Cite this

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title = "Incidence of dementia among participants and nonparticipants in a longitudinal study of cognitive aging",
abstract = "Although rates of incident dementia have been reported from several populations, the impact of nonparticipation on dementia incidence in studies of cognitive aging is unknown. In 2004, investigators with the Mayo Clinic Study of Aging selected persons aged 70-89 years from an enumeration of all Olmsted County, Minnesota, residents (ageand sex-stratified random sample). Of 4,398 potential participants, 2,050 agreed to undergo an in-person health assessment. Those participants were reevaluated in person using standard diagnostic procedures approximately every 15 months over a median follow-up period of 5.7 years (through September 15, 2013). There were 1,679 persons who refused any participation. A trained nurse abstractor reviewed the medical records of nonparticipants using the Rochester Epidemiology Project's medical record linkage system a median of 3.9 years after refusal. Nonparticipants had a higher prevalence of dementia than participants evaluated in person (6.5{\%} vs. 3.3{\%};P<0.0001). The standardized incidence of dementia was not significantly higher among the nonparticipants (23.2 per 1,000 person-years) than in those evaluated in person (19.6 per 1,000 person-years; hazard ratio = 1.17, 95{\%} confidence interval: 0.95, 1.43 (P =0.13); adjusted for education and sex, with age as the time scale). The small, nonsignificant impact of nonparticipation on rates of incident dementia is reassuring for future studies based on incident dementia cases.",
keywords = "Aging, Cognition, Cognitive aging, Dementia, Epidemiologic methods, Incidence, Prevalence",
author = "Knopman, {David S} and Roberts, {Rosebud O} and Pankratz, {V. Shane} and Cha, {Ruth H.} and Rocca, {Walter A} and Mielke, {Michelle M} and Boeve, {Bradley F} and Tangalos, {Eric George} and Ivnik, {Robert J.} and Geda, {Yonas Endale} and Petersen, {Ronald Carl}",
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AU - Knopman, David S

AU - Roberts, Rosebud O

AU - Pankratz, V. Shane

AU - Cha, Ruth H.

AU - Rocca, Walter A

AU - Mielke, Michelle M

AU - Boeve, Bradley F

AU - Tangalos, Eric George

AU - Ivnik, Robert J.

AU - Geda, Yonas Endale

AU - Petersen, Ronald Carl

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