Incidence of bullous pemphigoid and mortality of patients with bullous pemphigoid in Olmsted County, Minnesota, 1960 through 2009

Katherine E. Brick, Chad H. Weaver, Christine M. Lohse, Mark R. Pittelkow, Julia Lehman, Michael J. Camilleri, Mustafa Al-Hashimi, Carilyn N. Wieland

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Abstract

Background Bullous pemphigoid (BP) is an autoimmune blistering disease that is associated with increased mortality. Objective We sought to determine the incidence and mortality of patients with BP. Methods A total of 87 residents of Olmsted County, Minnesota, were identified who had their first lifetime diagnosis of BP from January 1960 through December 2009. Incidence and mortality were compared with age- and sex-matched control patients from the same geographic area. Results The adjusted incidence of BP was 2.4 per 100,000 person-years (95% confidence interval, 1.9-2.9). Incidence of BP increased significantly with age (P <.001) and over time (P =.034). Trend tests indicate increased diagnosis of localized disease (P =.006) may be a contributing factor. Survival observed in the incident BP cohort was significantly poorer than expected (P <.001). Survival was not different among patients with multisite versus localized disease (P =.90). Limitations Retrospective study design and study population from a small geographic area are limitations. Conclusion Incidence of BP in the United States is comparable with that found in Europe and Asia. The mortality of BP is lower in the United States than Europe, but higher than previous estimates.

Original languageEnglish (US)
Pages (from-to)92-99
Number of pages8
JournalJournal of the American Academy of Dermatology
Volume71
Issue number1
DOIs
StatePublished - Jan 1 2014

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Bullous Pemphigoid
Mortality
Incidence
Survival
Autoimmune Diseases
Retrospective Studies
Confidence Intervals

Keywords

  • autoimmune blistering disorder
  • bullous pemphigoid
  • epidemiology
  • geriatric
  • incidence
  • mortality

ASJC Scopus subject areas

  • Dermatology

Cite this

Incidence of bullous pemphigoid and mortality of patients with bullous pemphigoid in Olmsted County, Minnesota, 1960 through 2009. / Brick, Katherine E.; Weaver, Chad H.; Lohse, Christine M.; Pittelkow, Mark R.; Lehman, Julia; Camilleri, Michael J.; Al-Hashimi, Mustafa; Wieland, Carilyn N.

In: Journal of the American Academy of Dermatology, Vol. 71, No. 1, 01.01.2014, p. 92-99.

Research output: Contribution to journalArticle

Brick, Katherine E. ; Weaver, Chad H. ; Lohse, Christine M. ; Pittelkow, Mark R. ; Lehman, Julia ; Camilleri, Michael J. ; Al-Hashimi, Mustafa ; Wieland, Carilyn N. / Incidence of bullous pemphigoid and mortality of patients with bullous pemphigoid in Olmsted County, Minnesota, 1960 through 2009. In: Journal of the American Academy of Dermatology. 2014 ; Vol. 71, No. 1. pp. 92-99.
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abstract = "Background Bullous pemphigoid (BP) is an autoimmune blistering disease that is associated with increased mortality. Objective We sought to determine the incidence and mortality of patients with BP. Methods A total of 87 residents of Olmsted County, Minnesota, were identified who had their first lifetime diagnosis of BP from January 1960 through December 2009. Incidence and mortality were compared with age- and sex-matched control patients from the same geographic area. Results The adjusted incidence of BP was 2.4 per 100,000 person-years (95{\%} confidence interval, 1.9-2.9). Incidence of BP increased significantly with age (P <.001) and over time (P =.034). Trend tests indicate increased diagnosis of localized disease (P =.006) may be a contributing factor. Survival observed in the incident BP cohort was significantly poorer than expected (P <.001). Survival was not different among patients with multisite versus localized disease (P =.90). Limitations Retrospective study design and study population from a small geographic area are limitations. Conclusion Incidence of BP in the United States is comparable with that found in Europe and Asia. The mortality of BP is lower in the United States than Europe, but higher than previous estimates.",
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AB - Background Bullous pemphigoid (BP) is an autoimmune blistering disease that is associated with increased mortality. Objective We sought to determine the incidence and mortality of patients with BP. Methods A total of 87 residents of Olmsted County, Minnesota, were identified who had their first lifetime diagnosis of BP from January 1960 through December 2009. Incidence and mortality were compared with age- and sex-matched control patients from the same geographic area. Results The adjusted incidence of BP was 2.4 per 100,000 person-years (95% confidence interval, 1.9-2.9). Incidence of BP increased significantly with age (P <.001) and over time (P =.034). Trend tests indicate increased diagnosis of localized disease (P =.006) may be a contributing factor. Survival observed in the incident BP cohort was significantly poorer than expected (P <.001). Survival was not different among patients with multisite versus localized disease (P =.90). Limitations Retrospective study design and study population from a small geographic area are limitations. Conclusion Incidence of BP in the United States is comparable with that found in Europe and Asia. The mortality of BP is lower in the United States than Europe, but higher than previous estimates.

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