TY - JOUR
T1 - Incidence of bicuspid valve related aortic dissection
T2 - a systematic review and meta-analysis
AU - Wilson-Smith, Ashley R.
AU - Eranki, Aditya
AU - Muston, Benjamin
AU - Kamalanathan, Harish
AU - Yung, Amanda
AU - Williams, Michael L.
AU - Sahai, Prachi
AU - Zi, Caroline
AU - Michelena, Hector
N1 - Publisher Copyright:
© Annals of Cardiothoracic Surgery. All rights reserved.
PY - 2022/7
Y1 - 2022/7
N2 - Background: The true incidence of bicuspid valve-related aortic dissection (AD) is extremely difficult to ascertain. This review aimed to provide the reported cumulative incidence of bicuspid aortic valve (BAV)-related AD in actively monitored study populations. Methods: Four electronic databases were used to perform literature searches. A meta-analysis of proportions or means were performed for categorical and continuous variables, as appropriate. Survival data was calculated from the aggregation of Kaplan-Meier (KM) curves from the included studies, where reported. Results: A total of 4,330 patients were identified in eleven studies. A cumulative incidence of bicuspid valve-related AD of 0.6% across a median follow-up time of 9 years was identified. Actuarial survival across this monitored population at 1, 3, 5 and 10 years was 97.2%, 96.7%, 92.45%, and 81.1%, respectively. Conclusions: This systematic review and meta-analysis identified a low incidence of AD across the examined follow-up period. Large, prospective studies involving early identification of bicuspid valve pathology, recruitment, and follow-up of BAV cohorts with comparison to the baseline population are required to most accurately determine the outcomes of these patients.
AB - Background: The true incidence of bicuspid valve-related aortic dissection (AD) is extremely difficult to ascertain. This review aimed to provide the reported cumulative incidence of bicuspid aortic valve (BAV)-related AD in actively monitored study populations. Methods: Four electronic databases were used to perform literature searches. A meta-analysis of proportions or means were performed for categorical and continuous variables, as appropriate. Survival data was calculated from the aggregation of Kaplan-Meier (KM) curves from the included studies, where reported. Results: A total of 4,330 patients were identified in eleven studies. A cumulative incidence of bicuspid valve-related AD of 0.6% across a median follow-up time of 9 years was identified. Actuarial survival across this monitored population at 1, 3, 5 and 10 years was 97.2%, 96.7%, 92.45%, and 81.1%, respectively. Conclusions: This systematic review and meta-analysis identified a low incidence of AD across the examined follow-up period. Large, prospective studies involving early identification of bicuspid valve pathology, recruitment, and follow-up of BAV cohorts with comparison to the baseline population are required to most accurately determine the outcomes of these patients.
KW - Aortic dissection (ad)
KW - Bicuspid aortic valve (bav)
KW - Cumulative incidence
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U2 - 10.21037/ACS-2022-BAV-21
DO - 10.21037/ACS-2022-BAV-21
M3 - Article
AN - SCOPUS:85135391988
SN - 2225-319X
VL - 11
SP - 363
EP - 368
JO - Annals of Cardiothoracic Surgery
JF - Annals of Cardiothoracic Surgery
IS - 4
ER -