Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years

Leslie J. Christenson, Theresa A. Borrowman, Celine M Vachon, Megha M Tollefson, Clark C. Otley, Amy L. Weaver, Randall K. Roenigk

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Abstract

Context: The incidence of nonmelanoma skin cancer is increasing rapidly among elderly persons, but little is known about its incidence in the population younger than 40 years. Objectives: To estimate the sex- and age-specific incidences of basal cell carcinoma and squamous cell carcinoma in persons younger than 40 years in Olmsted County, Minnesota, and to evaluate change in incidence over time; to describe the clinical presentation, rate of recurrence and metastasis, and histologic characteristics of these tumors in this population-based sample. Design: Population-based retrospective incidence case review. Setting: Residents of Olmsted County, Minnesota, a population with comprehensive medical records captured through the Rochester Epidemiology Project. Participants: Patients younger than 40 years with basal cell carcinoma or squamous cell carcinoma diagnosed between 1976 and 2003. Main Outcome Measures: Incident basal cell carcinomas and squamous cell carcinomas and change in incidence of these tumors over time. Results: During the study period, 451 incident basal cell carcinomas were diagnosed in 417 patients and 70 incident squamous cell carcinomas were diagnosed in 68 patients. Of these tumors, 328 were histologically confirmed basal cell carcinomas and 51 were histologically confirmed squamous cell carcinomas. Overall, the ageadjusted incidence of basal cell carcinoma per 100 000 persons was 25.9 (95% confidence interval [CI], 22.6-29.2) for women and 20.9 (95% CI, 17.8-23.9) for men. The incidence of basal cell carcinoma increased significantly during the study period among women (P<.001) but not men (P=.19). Nodular basal cell carcinoma was the most common histologic subtype; 43.0% of tumors were solely nodular basal cell carcinoma and 11.0% had a mixed composition, including the nodular subtype. The incidence of squamous cell carcinoma was similar in men and women, with an average age- and sex-adjusted incidence per 100 000 persons of 3.9 (95% CI, 3.0-4.8); the incidence of squamous cell carcinoma increased significantly over the study period among both women (P=.01) and men (P=.04). Conclusions: This population-based study demonstrated an increase in the incidence of nonmelanoma skin cancer among young women and men residing in Olmsted County, Minnesota. There was a disproportionate increase in basal cell carcinoma in young women. This increase may lead to an exponential increase in the overall occurrence of nonmelanoma skin cancers over time as this population ages, which emphasizes the need to focus on skin cancer prevention in young adults.

Original languageEnglish (US)
Pages (from-to)681-690
Number of pages10
JournalJournal of the American Medical Association
Volume294
Issue number6
DOIs
StatePublished - Aug 10 2005

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Basal Cell Carcinoma
Squamous Cell Carcinoma
Incidence
Population
Skin Neoplasms
Confidence Intervals
Neoplasms
Medical Records
Young Adult
Epidemiology
Outcome Assessment (Health Care)
Neoplasm Metastasis
Recurrence

ASJC Scopus subject areas

  • Medicine(all)

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Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years. / Christenson, Leslie J.; Borrowman, Theresa A.; Vachon, Celine M; Tollefson, Megha M; Otley, Clark C.; Weaver, Amy L.; Roenigk, Randall K.

In: Journal of the American Medical Association, Vol. 294, No. 6, 10.08.2005, p. 681-690.

Research output: Contribution to journalArticle

Christenson, Leslie J. ; Borrowman, Theresa A. ; Vachon, Celine M ; Tollefson, Megha M ; Otley, Clark C. ; Weaver, Amy L. ; Roenigk, Randall K. / Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years. In: Journal of the American Medical Association. 2005 ; Vol. 294, No. 6. pp. 681-690.
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abstract = "Context: The incidence of nonmelanoma skin cancer is increasing rapidly among elderly persons, but little is known about its incidence in the population younger than 40 years. Objectives: To estimate the sex- and age-specific incidences of basal cell carcinoma and squamous cell carcinoma in persons younger than 40 years in Olmsted County, Minnesota, and to evaluate change in incidence over time; to describe the clinical presentation, rate of recurrence and metastasis, and histologic characteristics of these tumors in this population-based sample. Design: Population-based retrospective incidence case review. Setting: Residents of Olmsted County, Minnesota, a population with comprehensive medical records captured through the Rochester Epidemiology Project. Participants: Patients younger than 40 years with basal cell carcinoma or squamous cell carcinoma diagnosed between 1976 and 2003. Main Outcome Measures: Incident basal cell carcinomas and squamous cell carcinomas and change in incidence of these tumors over time. Results: During the study period, 451 incident basal cell carcinomas were diagnosed in 417 patients and 70 incident squamous cell carcinomas were diagnosed in 68 patients. Of these tumors, 328 were histologically confirmed basal cell carcinomas and 51 were histologically confirmed squamous cell carcinomas. Overall, the ageadjusted incidence of basal cell carcinoma per 100 000 persons was 25.9 (95{\%} confidence interval [CI], 22.6-29.2) for women and 20.9 (95{\%} CI, 17.8-23.9) for men. The incidence of basal cell carcinoma increased significantly during the study period among women (P<.001) but not men (P=.19). Nodular basal cell carcinoma was the most common histologic subtype; 43.0{\%} of tumors were solely nodular basal cell carcinoma and 11.0{\%} had a mixed composition, including the nodular subtype. The incidence of squamous cell carcinoma was similar in men and women, with an average age- and sex-adjusted incidence per 100 000 persons of 3.9 (95{\%} CI, 3.0-4.8); the incidence of squamous cell carcinoma increased significantly over the study period among both women (P=.01) and men (P=.04). Conclusions: This population-based study demonstrated an increase in the incidence of nonmelanoma skin cancer among young women and men residing in Olmsted County, Minnesota. There was a disproportionate increase in basal cell carcinoma in young women. This increase may lead to an exponential increase in the overall occurrence of nonmelanoma skin cancers over time as this population ages, which emphasizes the need to focus on skin cancer prevention in young adults.",
author = "Christenson, {Leslie J.} and Borrowman, {Theresa A.} and Vachon, {Celine M} and Tollefson, {Megha M} and Otley, {Clark C.} and Weaver, {Amy L.} and Roenigk, {Randall K.}",
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T1 - Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years

AU - Christenson, Leslie J.

AU - Borrowman, Theresa A.

AU - Vachon, Celine M

AU - Tollefson, Megha M

AU - Otley, Clark C.

AU - Weaver, Amy L.

AU - Roenigk, Randall K.

PY - 2005/8/10

Y1 - 2005/8/10

N2 - Context: The incidence of nonmelanoma skin cancer is increasing rapidly among elderly persons, but little is known about its incidence in the population younger than 40 years. Objectives: To estimate the sex- and age-specific incidences of basal cell carcinoma and squamous cell carcinoma in persons younger than 40 years in Olmsted County, Minnesota, and to evaluate change in incidence over time; to describe the clinical presentation, rate of recurrence and metastasis, and histologic characteristics of these tumors in this population-based sample. Design: Population-based retrospective incidence case review. Setting: Residents of Olmsted County, Minnesota, a population with comprehensive medical records captured through the Rochester Epidemiology Project. Participants: Patients younger than 40 years with basal cell carcinoma or squamous cell carcinoma diagnosed between 1976 and 2003. Main Outcome Measures: Incident basal cell carcinomas and squamous cell carcinomas and change in incidence of these tumors over time. Results: During the study period, 451 incident basal cell carcinomas were diagnosed in 417 patients and 70 incident squamous cell carcinomas were diagnosed in 68 patients. Of these tumors, 328 were histologically confirmed basal cell carcinomas and 51 were histologically confirmed squamous cell carcinomas. Overall, the ageadjusted incidence of basal cell carcinoma per 100 000 persons was 25.9 (95% confidence interval [CI], 22.6-29.2) for women and 20.9 (95% CI, 17.8-23.9) for men. The incidence of basal cell carcinoma increased significantly during the study period among women (P<.001) but not men (P=.19). Nodular basal cell carcinoma was the most common histologic subtype; 43.0% of tumors were solely nodular basal cell carcinoma and 11.0% had a mixed composition, including the nodular subtype. The incidence of squamous cell carcinoma was similar in men and women, with an average age- and sex-adjusted incidence per 100 000 persons of 3.9 (95% CI, 3.0-4.8); the incidence of squamous cell carcinoma increased significantly over the study period among both women (P=.01) and men (P=.04). Conclusions: This population-based study demonstrated an increase in the incidence of nonmelanoma skin cancer among young women and men residing in Olmsted County, Minnesota. There was a disproportionate increase in basal cell carcinoma in young women. This increase may lead to an exponential increase in the overall occurrence of nonmelanoma skin cancers over time as this population ages, which emphasizes the need to focus on skin cancer prevention in young adults.

AB - Context: The incidence of nonmelanoma skin cancer is increasing rapidly among elderly persons, but little is known about its incidence in the population younger than 40 years. Objectives: To estimate the sex- and age-specific incidences of basal cell carcinoma and squamous cell carcinoma in persons younger than 40 years in Olmsted County, Minnesota, and to evaluate change in incidence over time; to describe the clinical presentation, rate of recurrence and metastasis, and histologic characteristics of these tumors in this population-based sample. Design: Population-based retrospective incidence case review. Setting: Residents of Olmsted County, Minnesota, a population with comprehensive medical records captured through the Rochester Epidemiology Project. Participants: Patients younger than 40 years with basal cell carcinoma or squamous cell carcinoma diagnosed between 1976 and 2003. Main Outcome Measures: Incident basal cell carcinomas and squamous cell carcinomas and change in incidence of these tumors over time. Results: During the study period, 451 incident basal cell carcinomas were diagnosed in 417 patients and 70 incident squamous cell carcinomas were diagnosed in 68 patients. Of these tumors, 328 were histologically confirmed basal cell carcinomas and 51 were histologically confirmed squamous cell carcinomas. Overall, the ageadjusted incidence of basal cell carcinoma per 100 000 persons was 25.9 (95% confidence interval [CI], 22.6-29.2) for women and 20.9 (95% CI, 17.8-23.9) for men. The incidence of basal cell carcinoma increased significantly during the study period among women (P<.001) but not men (P=.19). Nodular basal cell carcinoma was the most common histologic subtype; 43.0% of tumors were solely nodular basal cell carcinoma and 11.0% had a mixed composition, including the nodular subtype. The incidence of squamous cell carcinoma was similar in men and women, with an average age- and sex-adjusted incidence per 100 000 persons of 3.9 (95% CI, 3.0-4.8); the incidence of squamous cell carcinoma increased significantly over the study period among both women (P=.01) and men (P=.04). Conclusions: This population-based study demonstrated an increase in the incidence of nonmelanoma skin cancer among young women and men residing in Olmsted County, Minnesota. There was a disproportionate increase in basal cell carcinoma in young women. This increase may lead to an exponential increase in the overall occurrence of nonmelanoma skin cancers over time as this population ages, which emphasizes the need to focus on skin cancer prevention in young adults.

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