Incidence of amyotrophic lateral sclerosis and of the parkinsonism-dementia complex of Guam, 1950-1989

Stephen C. Waring, Cony Esteban-Santillan, Dwayne M. Reed, Ulla Katrina Craig, Darwin R. Labarthe, Ronald C. Petersen, Leonard T. Kurland

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Studies representing the accumulated information from the first 30 years of research effort on Guam (1950-1979) have demonstrated a varying degree of decline in the incidence of amyotrophic lateral sclerosis (ALS) and the parkinsonism-dementia complex (PDC) of Guam. Analysis with more complete information for the period 1980-1989 provides more valid estimates of the later patterns in the incidence of ALS and PDC and affords a more extensive assessment of trends over a 40-year period. The annual age-adjusted incidence of ALS was 7/100,000 and the annual age-adjusted incidence of PDC was 22/100,000 in 1989. The incidence was much higher for the period 1980-1989 than suggested in previous reports. These findings provide compelling evidence that this spectrum of neurodegenerative diseases continues to have a significant impact on the health of the Chamorro people of Guam.

Original languageEnglish (US)
Pages (from-to)192-200
Number of pages9
JournalNeuroepidemiology
Volume23
Issue number4
DOIs
StatePublished - Jan 1 2004

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Keywords

  • Amyotrophic lateral sclerosis
  • Dementia
  • Guam
  • Incidence
  • Parkinsonism

ASJC Scopus subject areas

  • Epidemiology
  • Clinical Neurology

Cite this

Waring, S. C., Esteban-Santillan, C., Reed, D. M., Craig, U. K., Labarthe, D. R., Petersen, R. C., & Kurland, L. T. (2004). Incidence of amyotrophic lateral sclerosis and of the parkinsonism-dementia complex of Guam, 1950-1989. Neuroepidemiology, 23(4), 192-200. https://doi.org/10.1159/000078505