Incidence, correlates, management, and clinical outcome of coronary perforation: Analysis of 16,298 procedures

Panayotis Fasseas, James L. Orford, Carmelo J. Panetta, Malcolm R. Bell, Ali E. Denktas, Ryan J. Lennon, David R. Holmes, Peter B. Berger

Research output: Contribution to journalArticle

144 Scopus citations

Abstract

Background: Coronary perforation is a serious but uncommon complication of percutaneous coronary intervention (PCI) and is associated with significant morbidity and mortality. Methods: We performed an analysis of the Mayo Clinic PCI database. Clinical records, procedural reports, and angiographic studies were reviewed. Multiple logistic regression analysis was performed to identify clinical, procedural, anatomic, and angiographic correlates of coronary perforation. Results: A total of 16,298 PCI procedures were performed between January 1990 and December 2001. We identified 95 coronary perforations (0.58%; 95% CI, 0.47-0.71). The incidence of coronary perforation varied with time. Correlates of coronary perforation included the use of an atheroablative device and female sex. Twelve patients (12.6%) sustained an acute myocardial infarction, and cardiac tamponade developed in 11 patients (11.6%). Management strategies included reversal of heparin, pericardiocentesis, placement of a covered stent, and surgical repair. Seven patients died (7.4%). Conclusions: Coronary perforation during PCI is rare, but is associated with significant morbidity and mortality. The variable frequency of perforation may be explained by temporal variations in the use of atheroablative devices.

Original languageEnglish (US)
Pages (from-to)140-145
Number of pages6
JournalAmerican heart journal
Volume147
Issue number1
DOIs
StatePublished - Jan 2004

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Fasseas, P., Orford, J. L., Panetta, C. J., Bell, M. R., Denktas, A. E., Lennon, R. J., Holmes, D. R., & Berger, P. B. (2004). Incidence, correlates, management, and clinical outcome of coronary perforation: Analysis of 16,298 procedures. American heart journal, 147(1), 140-145. https://doi.org/10.1016/S0002-8703(03)00505-2