Incidence and Types of Pediatric Nystagmus

David L. Nash, Nancy N. Diehl, Brian G. Mohney

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose To report the incidence, prevalent subtypes, and clinical characteristics of pediatric nystagmus diagnosed over a 30-year period. Design Retrospective, population-based study. Methods Using the Rochester Epidemiology Project, we reviewed the medical records of all children (<19 years) diagnosed as residents in Olmsted County, Minnesota, with any form of nystagmus from January 1, 1976, through December 31, 2005. Results Seventy-one children were diagnosed during the 30-year period, yielding an annual incidence of 6.72 per 100,000 younger than 19 years (95% confidence interval [CI], 5.15–8.28) Infantile nystagmus, onset by 6 months, comprised 62 (87.3%) of the study patients, corresponding to a birth prevalence of 1 in 821. The median age at diagnosis for the cohort was 12.7 months (range, 0 days to 18.6 years) and 42 subjects (59.2%) were male. The main types of nystagmus, in declining order, were nystagmus associated with retinal/optic nerve disease in 23 (32.4%), idiopathic or congenital motor nystagmus in 22 (31.0%), manifest latent nystagmus or latent nystagmus in 17 (24.0%), and 2 (2.8%) each associated with Chiari malformation, medication use, tumor of the central nervous system, and no diagnosis. Developmental delay was diagnosed in 31 (43.6%), strabismus in 25 (35.2%), and amblyopia in 10 (14.1%). Eighty percent had 20/40 (or equivalent) or better vision at presentation in at least 1 eye. Conclusions This study provides population-based data on incidence and clinical characteristics of childhood nystagmus in North America. Idiopathic and nystagmus associated with retinal/optic nerve disease were the most common presentations, with most patients having good vision. Developmental delay, strabismus, and amblyopia were common in this cohort.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalAmerican Journal of Ophthalmology
Volume182
DOIs
StatePublished - Oct 1 2017

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Optic Nerve Diseases
Amblyopia
Strabismus
Pediatrics
Incidence
Central Nervous System Neoplasms
North America
Population
Medical Records
Epidemiology
Parturition
Confidence Intervals
X-Linked Infantile Nystagmus

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Incidence and Types of Pediatric Nystagmus. / Nash, David L.; Diehl, Nancy N.; Mohney, Brian G.

In: American Journal of Ophthalmology, Vol. 182, 01.10.2017, p. 31-34.

Research output: Contribution to journalArticle

Nash, David L. ; Diehl, Nancy N. ; Mohney, Brian G. / Incidence and Types of Pediatric Nystagmus. In: American Journal of Ophthalmology. 2017 ; Vol. 182. pp. 31-34.
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abstract = "Purpose To report the incidence, prevalent subtypes, and clinical characteristics of pediatric nystagmus diagnosed over a 30-year period. Design Retrospective, population-based study. Methods Using the Rochester Epidemiology Project, we reviewed the medical records of all children (<19 years) diagnosed as residents in Olmsted County, Minnesota, with any form of nystagmus from January 1, 1976, through December 31, 2005. Results Seventy-one children were diagnosed during the 30-year period, yielding an annual incidence of 6.72 per 100,000 younger than 19 years (95{\%} confidence interval [CI], 5.15–8.28) Infantile nystagmus, onset by 6 months, comprised 62 (87.3{\%}) of the study patients, corresponding to a birth prevalence of 1 in 821. The median age at diagnosis for the cohort was 12.7 months (range, 0 days to 18.6 years) and 42 subjects (59.2{\%}) were male. The main types of nystagmus, in declining order, were nystagmus associated with retinal/optic nerve disease in 23 (32.4{\%}), idiopathic or congenital motor nystagmus in 22 (31.0{\%}), manifest latent nystagmus or latent nystagmus in 17 (24.0{\%}), and 2 (2.8{\%}) each associated with Chiari malformation, medication use, tumor of the central nervous system, and no diagnosis. Developmental delay was diagnosed in 31 (43.6{\%}), strabismus in 25 (35.2{\%}), and amblyopia in 10 (14.1{\%}). Eighty percent had 20/40 (or equivalent) or better vision at presentation in at least 1 eye. Conclusions This study provides population-based data on incidence and clinical characteristics of childhood nystagmus in North America. Idiopathic and nystagmus associated with retinal/optic nerve disease were the most common presentations, with most patients having good vision. Developmental delay, strabismus, and amblyopia were common in this cohort.",
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