Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention

Charanjit S. Rihal, Stephen C. Textor, Diane E. Grill, Peter B. Berger, Henry H. Ting, Patricia J. Best, Mandeep Singh, Malcolm R. Bell, Gregory W. Barsness, Verghese Mathew, Kirk N. Garratt, David R. Holmes

Research output: Contribution to journalArticle

1286 Scopus citations

Abstract

Background - In patients undergoing percutaneous coronary intervention (PCI) in the modern era, the incidence and prognostic implications of acute renal failure (ARF) are unknown. Methods and Results - With a retrospective analysis of the Mayo Clinic PCI registry, we determined the incidence of, risk factors for, and prognostic implications of ARF (defined as an increase in serum creatinine [Cr] >0.5 mg/dL from baseline) after PCI. Of 7586 patients, 254 (3.3%) experienced ARF. Among patients with baseline Cr <2.0, the risk of ARF was higher among diabetic than nondiabetic patients, whereas among those with a baseline Cr >2.0, all had a significant risk of ARF. In multivariate analysis, ARF was associated with baseline serum Cr, acute myocardial infarction, shock, and volume of contrast medium administered. Twenty-two percent of patients with ARF died during the index hospitalization compared with only 1.4% of patients without ARF (P<0.0001). After adjustment, ARF remained strongly associated with death. Among hospital survivors with ARF, 1- and 5-year estimated mortality rates were 12.1% and 44.6%, respectively, much greater than the 3.7% and 14.5% mortality rates in patients without ARF (P<0.0001). Conclusions - The overall incidence of ARF after PCI is low. Diabetic patients with baseline Cr values <2.0 mg/dL are at higher risk than nondiabetic patients, whereas all patients with a serum Cr >2.0 are at high risk for ARF. ARF was highly correlated with death during the index hospitalization and after dismissal.

Original languageEnglish (US)
Pages (from-to)2259-2264
Number of pages6
JournalCirculation
Volume105
Issue number19
DOIs
StatePublished - May 14 2002

Keywords

  • Acute renal failure
  • Angioplasty
  • Coronary disease
  • Kidney
  • Stents

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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  • Cite this

    Rihal, C. S., Textor, S. C., Grill, D. E., Berger, P. B., Ting, H. H., Best, P. J., Singh, M., Bell, M. R., Barsness, G. W., Mathew, V., Garratt, K. N., & Holmes, D. R. (2002). Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention. Circulation, 105(19), 2259-2264. https://doi.org/10.1161/01.CIR.0000016043.87291.33