Incidence and Predictors of Infective Endocarditis in Mitral Valve Prolapse: A Population-Based Study

Ognjen Katan, Hector I Michelena, Jean Francois Avierinos, Douglas W. Mahoney, Daniel C. DeSimone, Larry M. Baddour, Rakesh M. Suri, Maurice E Sarano

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Abstract

Objective To determine the incidence and predictors of infective endocarditis (IE) in a population-based cohort of patients with mitral valve prolapse (MVP). Patients and Methods We identified all adult Olmsted County residents with MVP diagnosed by echocardiography from January 1989 to December 1998 and cross-matched them with the Rochester Epidemiology Project-identified Olmsted County cases of IE from January 1, 1986, through December 31, 2006. We retrospectively analyzed and de novo confirmed each IE case using the modified Duke criteria. Results There were 896 Olmsted County residents with echocardiographically diagnosed MVP (mean age, 53±21 years; 565 women [63%]). The mean follow-up period was 11±5 years. The 15-year cohort risk of IE after MVP diagnosis was 1.1%±0.4% (incidence, 86.6 cases per 100,000 person-years; 95% CI, 43.3-173.2 cases per 100,000 person-years); thus, the age- and sex-adjusted relative risk of IE in patients with MVP was 8.1 (95% CI, 3.6-18.0) in comparison to the general population of Olmsted County (P

Original languageEnglish (US)
Pages (from-to)336-342
Number of pages7
JournalMayo Clinic Proceedings
Volume91
Issue number3
DOIs
StatePublished - Mar 1 2016

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Mitral Valve Prolapse
Endocarditis
Incidence
Population
Echocardiography
Epidemiology

ASJC Scopus subject areas

  • Medicine(all)

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Incidence and Predictors of Infective Endocarditis in Mitral Valve Prolapse : A Population-Based Study. / Katan, Ognjen; Michelena, Hector I; Avierinos, Jean Francois; Mahoney, Douglas W.; DeSimone, Daniel C.; Baddour, Larry M.; Suri, Rakesh M.; Sarano, Maurice E.

In: Mayo Clinic Proceedings, Vol. 91, No. 3, 01.03.2016, p. 336-342.

Research output: Contribution to journalArticle

Katan, Ognjen ; Michelena, Hector I ; Avierinos, Jean Francois ; Mahoney, Douglas W. ; DeSimone, Daniel C. ; Baddour, Larry M. ; Suri, Rakesh M. ; Sarano, Maurice E. / Incidence and Predictors of Infective Endocarditis in Mitral Valve Prolapse : A Population-Based Study. In: Mayo Clinic Proceedings. 2016 ; Vol. 91, No. 3. pp. 336-342.
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N2 - Objective To determine the incidence and predictors of infective endocarditis (IE) in a population-based cohort of patients with mitral valve prolapse (MVP). Patients and Methods We identified all adult Olmsted County residents with MVP diagnosed by echocardiography from January 1989 to December 1998 and cross-matched them with the Rochester Epidemiology Project-identified Olmsted County cases of IE from January 1, 1986, through December 31, 2006. We retrospectively analyzed and de novo confirmed each IE case using the modified Duke criteria. Results There were 896 Olmsted County residents with echocardiographically diagnosed MVP (mean age, 53±21 years; 565 women [63%]). The mean follow-up period was 11±5 years. The 15-year cohort risk of IE after MVP diagnosis was 1.1%±0.4% (incidence, 86.6 cases per 100,000 person-years; 95% CI, 43.3-173.2 cases per 100,000 person-years); thus, the age- and sex-adjusted relative risk of IE in patients with MVP was 8.1 (95% CI, 3.6-18.0) in comparison to the general population of Olmsted County (P

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