Incidence and clinical characteristics of periocular infantile hemangiomas

Saba T. Alniemi, Gregory J. Griepentrog, Nancy Diehl, Brian G. Mohney

Research output: Contribution to journalArticle

7 Scopus citations


Objective: To report the incidence, demographics, and clinical findings among a population-based cohort of children with periocular infantile hemangiomas. Methods: The medical records of all patients (<19 years of age) diagnosed as having periocular infantile hemangiomas while residing in Olmsted County, Minnesota, from January 1, 1965, through December 31, 2004, were retrospectively reviewed. Results: Forty-three children were diagnosed as having periocular infantile hemangiomas during the 40- year period, yielding an incidence of 5.4 per 100 000 individuals younger than 19 years (95% CI, 3.8-7.1) or a birth prevalence of 1 in 1586 live births. Thirty children (70%) were female (P<.001). There was a history of maternal infertility in approximately 1 in 5 children and premature birth in 1 in 8 children. Twenty-six children (61%) had other abnormalities, including secondary hemangiomas in 9 (21%). Forty-one patients (95%) had unilateral disease, and 37 hemangiomas (86%) were located on the upper eyelid. Conclusions: In this population-based study, periocular infantile hemangiomas occurred in 1 in 1586 live births and were most prevalent on the unilateral upper eyelid of white female patients. Prevalent associations included maternal infertility and premature birth. Other abnormalities, including secondary hemangiomas in 1 in 5 children, were common in this cohort.

Original languageEnglish (US)
Pages (from-to)889-894
Number of pages6
JournalArchives of Ophthalmology
Issue number7
StatePublished - Jul 2012


ASJC Scopus subject areas

  • Ophthalmology

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