TY - JOUR
T1 - Incidence and clinical characteristics of periocular infantile hemangiomas
AU - Alniemi, Saba T.
AU - Griepentrog, Gregory J.
AU - Diehl, Nancy
AU - Mohney, Brian G.
PY - 2012/7
Y1 - 2012/7
N2 - Objective: To report the incidence, demographics, and clinical findings among a population-based cohort of children with periocular infantile hemangiomas. Methods: The medical records of all patients (<19 years of age) diagnosed as having periocular infantile hemangiomas while residing in Olmsted County, Minnesota, from January 1, 1965, through December 31, 2004, were retrospectively reviewed. Results: Forty-three children were diagnosed as having periocular infantile hemangiomas during the 40- year period, yielding an incidence of 5.4 per 100 000 individuals younger than 19 years (95% CI, 3.8-7.1) or a birth prevalence of 1 in 1586 live births. Thirty children (70%) were female (P<.001). There was a history of maternal infertility in approximately 1 in 5 children and premature birth in 1 in 8 children. Twenty-six children (61%) had other abnormalities, including secondary hemangiomas in 9 (21%). Forty-one patients (95%) had unilateral disease, and 37 hemangiomas (86%) were located on the upper eyelid. Conclusions: In this population-based study, periocular infantile hemangiomas occurred in 1 in 1586 live births and were most prevalent on the unilateral upper eyelid of white female patients. Prevalent associations included maternal infertility and premature birth. Other abnormalities, including secondary hemangiomas in 1 in 5 children, were common in this cohort.
AB - Objective: To report the incidence, demographics, and clinical findings among a population-based cohort of children with periocular infantile hemangiomas. Methods: The medical records of all patients (<19 years of age) diagnosed as having periocular infantile hemangiomas while residing in Olmsted County, Minnesota, from January 1, 1965, through December 31, 2004, were retrospectively reviewed. Results: Forty-three children were diagnosed as having periocular infantile hemangiomas during the 40- year period, yielding an incidence of 5.4 per 100 000 individuals younger than 19 years (95% CI, 3.8-7.1) or a birth prevalence of 1 in 1586 live births. Thirty children (70%) were female (P<.001). There was a history of maternal infertility in approximately 1 in 5 children and premature birth in 1 in 8 children. Twenty-six children (61%) had other abnormalities, including secondary hemangiomas in 9 (21%). Forty-one patients (95%) had unilateral disease, and 37 hemangiomas (86%) were located on the upper eyelid. Conclusions: In this population-based study, periocular infantile hemangiomas occurred in 1 in 1586 live births and were most prevalent on the unilateral upper eyelid of white female patients. Prevalent associations included maternal infertility and premature birth. Other abnormalities, including secondary hemangiomas in 1 in 5 children, were common in this cohort.
UR - http://www.scopus.com/inward/record.url?scp=84863794853&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863794853&partnerID=8YFLogxK
U2 - 10.1001/archophthalmol.2012.213
DO - 10.1001/archophthalmol.2012.213
M3 - Article
C2 - 22776927
AN - SCOPUS:84863794853
SN - 0003-9950
VL - 130
SP - 889
EP - 894
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 7
ER -