Incidence and causes of nondegenerative nonvascular dementia

A population-based study

David S Knopman, Ronald Carl Petersen, Ruth H. Cha, Steven D. Edland, Walter A Rocca

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Background: Information on the incidence of nondegenerative and nonvascular dementia is limited. Design: We used the records-linkage system of the Rochester Epidemiology Project to ascertain incident cases of dementia in Rochester, Minn, from January 1, 1990, through December 31, 1994. To define causes of dementia, we reviewed all diagnoses, imaging study results, laboratory test results, and clinical courses, as recorded historically in the patient dossier. Results: We found 560 incident cases of dementia, and 60 of them (10.7%) had onset before the age of 70 years (younger-onset group). Forty-three cases (7.7%) were due to nondegenerative nonvascular causes and represented 30.0% of the total in the younger-onset group, but only 5.0% of the total in the older-onset group (aged 70-99 years). The most common nondegenerative nonvascular causes were cancer with or without brain metastases (n=13), chronic alcoholism (n=7), and chronic mental illness (n=11). There were no cases of dementia due to normal-pressure hydrocephalus, subdural hematoma, hypothyroidism, vitamin B12 deficiency, or neurosyphilis. There were 2 individuals with acute confusion due to subdural hematoma and 1 with hypothyroidism whose cognition normalized with therapy. Conclusions: Nondegenerative nonvascular causes were more common than expected in patients with a younger onset of dementia. None of the patients with dementia reverted to normal with treatment of the putative reversible cause.

Original languageEnglish (US)
Pages (from-to)218-221
Number of pages4
JournalArchives of Neurology
Volume63
Issue number2
DOIs
StatePublished - Feb 2006

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Dementia
Incidence
Population
Subdural Hematoma
Hypothyroidism
Normal Pressure Hydrocephalus
Neurosyphilis
Vitamin B 12 Deficiency
Confusion
Causes
Age of Onset
Cognition
Alcoholism
Epidemiology
Chronic Disease
Onset
Neoplasm Metastasis
Brain
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Incidence and causes of nondegenerative nonvascular dementia : A population-based study. / Knopman, David S; Petersen, Ronald Carl; Cha, Ruth H.; Edland, Steven D.; Rocca, Walter A.

In: Archives of Neurology, Vol. 63, No. 2, 02.2006, p. 218-221.

Research output: Contribution to journalArticle

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