Inadvertent Aluminum Administration during Plasma Exchange Due to Aluminum Contamination of Albumin-Replacement Solutions

Dawn S. Milliner, James H. Shinaberger, Patty Shuman, Jack W. Coburn

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

ALUMINUM can accumulate in patients with reduced renal function due to impaired excretion of aluminum1,2 and in patients with normal renal function who receive large parenteral amounts of aluminum.3 Manifestations of aluminum toxicity include vitamin D–refractory osteodystrophy, hypercalcemia, anemia, and severe progressive encephalopathy.4 5 6 Aluminum-related osteodystrophy is characterized by increased bone aluminum content, with aluminum deposits along the mineralization front, impaired mineralization, and a reduced rate of bone formation.7 Clinical correlates of the bone abnormalities include bone pain, proximal myopathy, and in some patients pathologic fractures.8 Aluminum-related encephalopathy is frequently fatal.9 Recognized sources of aluminum include water used for dialysis, solutions.

Original languageEnglish (US)
Pages (from-to)165-167
Number of pages3
JournalNew England Journal of Medicine
Volume312
Issue number3
DOIs
StatePublished - Jan 17 1985

ASJC Scopus subject areas

  • Medicine(all)

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