TY - JOUR
T1 - Inadvertent Aluminum Administration during Plasma Exchange Due to Aluminum Contamination of Albumin-Replacement Solutions
AU - Milliner, Dawn S.
AU - Shinaberger, James H.
AU - Shuman, Patty
AU - Coburn, Jack W.
PY - 1985/1/17
Y1 - 1985/1/17
N2 - ALUMINUM can accumulate in patients with reduced renal function due to impaired excretion of aluminum1,2 and in patients with normal renal function who receive large parenteral amounts of aluminum.3 Manifestations of aluminum toxicity include vitamin D–refractory osteodystrophy, hypercalcemia, anemia, and severe progressive encephalopathy.4 5 6 Aluminum-related osteodystrophy is characterized by increased bone aluminum content, with aluminum deposits along the mineralization front, impaired mineralization, and a reduced rate of bone formation.7 Clinical correlates of the bone abnormalities include bone pain, proximal myopathy, and in some patients pathologic fractures.8 Aluminum-related encephalopathy is frequently fatal.9 Recognized sources of aluminum include water used for dialysis, solutions.
AB - ALUMINUM can accumulate in patients with reduced renal function due to impaired excretion of aluminum1,2 and in patients with normal renal function who receive large parenteral amounts of aluminum.3 Manifestations of aluminum toxicity include vitamin D–refractory osteodystrophy, hypercalcemia, anemia, and severe progressive encephalopathy.4 5 6 Aluminum-related osteodystrophy is characterized by increased bone aluminum content, with aluminum deposits along the mineralization front, impaired mineralization, and a reduced rate of bone formation.7 Clinical correlates of the bone abnormalities include bone pain, proximal myopathy, and in some patients pathologic fractures.8 Aluminum-related encephalopathy is frequently fatal.9 Recognized sources of aluminum include water used for dialysis, solutions.
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U2 - 10.1056/NEJM198501173120307
DO - 10.1056/NEJM198501173120307
M3 - Article
C2 - 3965935
AN - SCOPUS:0022006733
SN - 0028-4793
VL - 312
SP - 165
EP - 167
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 3
ER -