TY - JOUR
T1 - In vivo temperature mapping of prostate during treatment with TherMatrx TMx-2000 device
T2 - Heat field and MRI determinations of necrotic lesions
AU - Larson, Benjamin
AU - Huidobro, Christian
AU - Acevedo, Cristian
AU - Busel, David
AU - Mynderses, Lance
AU - Collins, Joseph
AU - Larson, Thayne
PY - 2005/10
Y1 - 2005/10
N2 - Background and Purpose: The effectiveness of any thermotherapy device is determined by the temperatures created and how long they are applied. Understanding the heating characteristics of a thermotherapy device is vital to its correct implementation. Interstitial temperature mapping was used to determine the heat field created within the prostate by the TherMatrx TMx-2000 transurethral microwave thermotherapy (TUMT) device. Gadolinium-enhanced MRI was used to determine the extent, type, and pattern of coagulation necrosis caused by TUMT. Patients and Methods: Interstitial temperature mapping was performed during treatment in five patients with benign prostatic hyperplasia using 24 temperature sensors inserted through the perineum and arrayed throughout the prostate under ultrasound and X-ray guidance. Gadolinium-enhanced MRI scans were performed on all patients 1 week after treatment. Results: Interstitial temperature mapping found the heat field created to peak at the urethral surface near the central part of the catheter antenna. Temperatures decreased at consistent rates of 1 to 1.4°C/mm radially and 0.1 to 0.5°C/mm longitudinally from the peak area. Gadolinium-enhanced MRI showed minimal dispersed necrosis and only in the periurethral area. Conclusions: The TMx-2000 can create temperatures >45°C in areas 3 to 4 mm from the antenna. How ever, the heat pattern and protocol of the TMx-2000 produce necrosis-generating conditions only within a few millimeters of the urethra.
AB - Background and Purpose: The effectiveness of any thermotherapy device is determined by the temperatures created and how long they are applied. Understanding the heating characteristics of a thermotherapy device is vital to its correct implementation. Interstitial temperature mapping was used to determine the heat field created within the prostate by the TherMatrx TMx-2000 transurethral microwave thermotherapy (TUMT) device. Gadolinium-enhanced MRI was used to determine the extent, type, and pattern of coagulation necrosis caused by TUMT. Patients and Methods: Interstitial temperature mapping was performed during treatment in five patients with benign prostatic hyperplasia using 24 temperature sensors inserted through the perineum and arrayed throughout the prostate under ultrasound and X-ray guidance. Gadolinium-enhanced MRI scans were performed on all patients 1 week after treatment. Results: Interstitial temperature mapping found the heat field created to peak at the urethral surface near the central part of the catheter antenna. Temperatures decreased at consistent rates of 1 to 1.4°C/mm radially and 0.1 to 0.5°C/mm longitudinally from the peak area. Gadolinium-enhanced MRI showed minimal dispersed necrosis and only in the periurethral area. Conclusions: The TMx-2000 can create temperatures >45°C in areas 3 to 4 mm from the antenna. How ever, the heat pattern and protocol of the TMx-2000 produce necrosis-generating conditions only within a few millimeters of the urethra.
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U2 - 10.1089/end.2005.19.1021
DO - 10.1089/end.2005.19.1021
M3 - Article
C2 - 16253074
AN - SCOPUS:27744506591
SN - 0892-7790
VL - 19
SP - 1021
EP - 1025
JO - Journal of endourology
JF - Journal of endourology
IS - 8
ER -