In vivo target-specific delivery of macromolecular agents with MR- guided focused ultrasound

Mark D. Bednarski, James W. Lee, Matthew R. Callstrom, King C.P. Li

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Magnetic resonance (MR) images in rabbit muscle were used to select a target region for application of pulsed-focused ultrasound. Liposomes encapsulating gadopentetate dimeglumine, an MR-detectable model representing pharmaceutical agents, were then injected intravenously. Focal enhancement on T1-weighted images, representing gadolinium-liposome accumulation, occurred in the pulsed-focused-ultrasound focal zone. Therefore, MR-guided pulsed- focused ultrasound targeted the delivery of macromolecular pharmaceutical agents within tissues.

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
JournalRadiology
Volume204
Issue number1
DOIs
StatePublished - Jul 1997

Keywords

  • Gadolinium
  • Magnetic resonance (MR), guidance
  • Ultrasound (US), focused
  • Ultrasound (US), technology, Ultrasound (US), therapeutic

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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