In vivo studies on receptor pharmacology of the human eccrine sweat gland

Phillip Anson Low, Tonette L. Opfer-Gehrking, Mikihiro Kihara

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The receptor pharmacology of the human sweat gland was studied in vivo. The axon-reflex response was mediated by nicotinic receptors which were activated by nicotine and acetylcholine, but not pilocarpine, and inhibited by hexamethonium. The direct response was mainly muscarinic, responding to pilocarpine and acetylcholine. A component of the direct response was nicotinic, since it was activated by nicotine and blocked by hexamethonium in a dose-dependent manner. The axon-reflex response to nicotine and acetylcholine was partially blocked by pilocarpine, especially when application of pilocarpine preceded the procedure. The inhibition of the nicotinic response may be secondary to M1 antagonism since pilocarpine is an M2 agonist and M1 antagonist and pirenzepine, a specific M1 antagonist, caused similar effects as pilocarpine.

Original languageEnglish (US)
Pages (from-to)29-34
Number of pages6
JournalClinical Autonomic Research
Volume2
Issue number1
DOIs
StatePublished - Feb 1992

Fingerprint

Eccrine Glands
Sweat Glands
Pilocarpine
Pharmacology
Nicotine
Acetylcholine
Hexamethonium
Axons
Reflex
Pirenzepine
Nicotinic Receptors
Cholinergic Agents

Keywords

  • Muscarinic
  • Nicotinic
  • Receptor
  • Sweat gland

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

In vivo studies on receptor pharmacology of the human eccrine sweat gland. / Low, Phillip Anson; Opfer-Gehrking, Tonette L.; Kihara, Mikihiro.

In: Clinical Autonomic Research, Vol. 2, No. 1, 02.1992, p. 29-34.

Research output: Contribution to journalArticle

Low, Phillip Anson ; Opfer-Gehrking, Tonette L. ; Kihara, Mikihiro. / In vivo studies on receptor pharmacology of the human eccrine sweat gland. In: Clinical Autonomic Research. 1992 ; Vol. 2, No. 1. pp. 29-34.
@article{e4643846a174460a86b992252912c08c,
title = "In vivo studies on receptor pharmacology of the human eccrine sweat gland",
abstract = "The receptor pharmacology of the human sweat gland was studied in vivo. The axon-reflex response was mediated by nicotinic receptors which were activated by nicotine and acetylcholine, but not pilocarpine, and inhibited by hexamethonium. The direct response was mainly muscarinic, responding to pilocarpine and acetylcholine. A component of the direct response was nicotinic, since it was activated by nicotine and blocked by hexamethonium in a dose-dependent manner. The axon-reflex response to nicotine and acetylcholine was partially blocked by pilocarpine, especially when application of pilocarpine preceded the procedure. The inhibition of the nicotinic response may be secondary to M1 antagonism since pilocarpine is an M2 agonist and M1 antagonist and pirenzepine, a specific M1 antagonist, caused similar effects as pilocarpine.",
keywords = "Muscarinic, Nicotinic, Receptor, Sweat gland",
author = "Low, {Phillip Anson} and Opfer-Gehrking, {Tonette L.} and Mikihiro Kihara",
year = "1992",
month = "2",
doi = "10.1007/BF01824208",
language = "English (US)",
volume = "2",
pages = "29--34",
journal = "Clinical Autonomic Research",
issn = "0959-9851",
publisher = "D. Steinkopff-Verlag",
number = "1",

}

TY - JOUR

T1 - In vivo studies on receptor pharmacology of the human eccrine sweat gland

AU - Low, Phillip Anson

AU - Opfer-Gehrking, Tonette L.

AU - Kihara, Mikihiro

PY - 1992/2

Y1 - 1992/2

N2 - The receptor pharmacology of the human sweat gland was studied in vivo. The axon-reflex response was mediated by nicotinic receptors which were activated by nicotine and acetylcholine, but not pilocarpine, and inhibited by hexamethonium. The direct response was mainly muscarinic, responding to pilocarpine and acetylcholine. A component of the direct response was nicotinic, since it was activated by nicotine and blocked by hexamethonium in a dose-dependent manner. The axon-reflex response to nicotine and acetylcholine was partially blocked by pilocarpine, especially when application of pilocarpine preceded the procedure. The inhibition of the nicotinic response may be secondary to M1 antagonism since pilocarpine is an M2 agonist and M1 antagonist and pirenzepine, a specific M1 antagonist, caused similar effects as pilocarpine.

AB - The receptor pharmacology of the human sweat gland was studied in vivo. The axon-reflex response was mediated by nicotinic receptors which were activated by nicotine and acetylcholine, but not pilocarpine, and inhibited by hexamethonium. The direct response was mainly muscarinic, responding to pilocarpine and acetylcholine. A component of the direct response was nicotinic, since it was activated by nicotine and blocked by hexamethonium in a dose-dependent manner. The axon-reflex response to nicotine and acetylcholine was partially blocked by pilocarpine, especially when application of pilocarpine preceded the procedure. The inhibition of the nicotinic response may be secondary to M1 antagonism since pilocarpine is an M2 agonist and M1 antagonist and pirenzepine, a specific M1 antagonist, caused similar effects as pilocarpine.

KW - Muscarinic

KW - Nicotinic

KW - Receptor

KW - Sweat gland

UR - http://www.scopus.com/inward/record.url?scp=0026813340&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026813340&partnerID=8YFLogxK

U2 - 10.1007/BF01824208

DO - 10.1007/BF01824208

M3 - Article

C2 - 1638102

AN - SCOPUS:0026813340

VL - 2

SP - 29

EP - 34

JO - Clinical Autonomic Research

JF - Clinical Autonomic Research

SN - 0959-9851

IS - 1

ER -