In vivo studies on receptor pharmacology of the human eccrine sweat gland

Phillip A. Low; Tonette L. Opfer-Gehrking; Mikihiro Kihara

doi:10.1007/BF01824208

In vivo studies on receptor pharmacology of the human eccrine sweat gland

Phillip A. Low, Tonette L. Opfer-Gehrking, Mikihiro Kihara

Neurology

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

The receptor pharmacology of the human sweat gland was studied in vivo. The axon-reflex response was mediated by nicotinic receptors which were activated by nicotine and acetylcholine, but not pilocarpine, and inhibited by hexamethonium. The direct response was mainly muscarinic, responding to pilocarpine and acetylcholine. A component of the direct response was nicotinic, since it was activated by nicotine and blocked by hexamethonium in a dose-dependent manner. The axon-reflex response to nicotine and acetylcholine was partially blocked by pilocarpine, especially when application of pilocarpine preceded the procedure. The inhibition of the nicotinic response may be secondary to M₁ antagonism since pilocarpine is an M₂ agonist and M₁ antagonist and pirenzepine, a specific M₁ antagonist, caused similar effects as pilocarpine.

Original language	English (US)
Pages (from-to)	29-34
Number of pages	6
Journal	Clinical Autonomic Research
Volume	2
Issue number	1
DOIs	https://doi.org/10.1007/BF01824208
State	Published - Feb 1992

Keywords

Muscarinic
Nicotinic
Receptor
Sweat gland

ASJC Scopus subject areas

Endocrine and Autonomic Systems
Clinical Neurology

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10.1007/BF01824208

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In vivo studies on receptor pharmacology of the human eccrine sweat gland

Abstract

Keywords

ASJC Scopus subject areas

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