Abstract
Kiechle et al. present two transgenic mouse models that allow direct quantitative and spatial detection of α-synuclein (α-syn) oligomers in vivo. They demonstrate α-syn aggregation at the synapse, age-dependent accumulation of 8–16-mer α-syn oligomer species, and trans-cellular oligomer spreading from forebrain to hindbrain neurons.
Original language | English (US) |
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Pages (from-to) | 2862-2874.e9 |
Journal | Cell reports |
Volume | 29 |
Issue number | 9 |
DOIs | |
State | Published - Nov 26 2019 |
Keywords
- Parkinson's disease
- aging
- alpha-synuclein
- neurodegeneration
- oligomerization
- progressive phenotype
- protein-fragment complementation
- spreading
- synaptic oligomers
- transgenic mouse model
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology