In Vivo Imaging and Tumor Therapy with the Sodium Iodide Symporter

Research output: Contribution to journalReview article

70 Scopus citations

Abstract

There has been great progress in the design of vectors for cancer gene therapy. However, it has been difficult to translate success in the laboratory into clinical practice. A major hurdle in understanding these failures has been the relative difficulty in monitoring repeatedly and non-invasively the biodistribution, gene expression and replication of these viral vector systems. With the advent of molecular imaging technology, this deficiency is being rapidly rectified. A number of reporter genes have been used to monitor gene expression. In this review, we discuss the role of the sodium iodide symporter (NIS) as a reporter and therapeutic gene for cancer gene therapy when combined with various radioactive isotopes.

Original languageEnglish (US)
Pages (from-to)1079-1086
Number of pages8
JournalJournal of cellular biochemistry
Volume90
Issue number6
DOIs
StatePublished - Dec 15 2003

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Keywords

  • Biodistribution
  • Gene therapy
  • NIS

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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