In Vivo Imaging and Tumor Therapy with the Sodium Iodide Symporter

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

There has been great progress in the design of vectors for cancer gene therapy. However, it has been difficult to translate success in the laboratory into clinical practice. A major hurdle in understanding these failures has been the relative difficulty in monitoring repeatedly and non-invasively the biodistribution, gene expression and replication of these viral vector systems. With the advent of molecular imaging technology, this deficiency is being rapidly rectified. A number of reporter genes have been used to monitor gene expression. In this review, we discuss the role of the sodium iodide symporter (NIS) as a reporter and therapeutic gene for cancer gene therapy when combined with various radioactive isotopes.

Original languageEnglish (US)
Pages (from-to)1079-1086
Number of pages8
JournalJournal of Cellular Biochemistry
Volume90
Issue number6
DOIs
StatePublished - Dec 15 2003

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Gene therapy
Neoplasm Genes
Reporter Genes
Gene expression
Genetic Therapy
Tumors
Genes
Clinical laboratories
Molecular imaging
Gene Expression
Imaging techniques
Molecular Imaging
Radioisotopes
Neoplasms
Technology
Monitoring
Therapeutics
sodium-iodide symporter

Keywords

  • Biodistribution
  • Gene therapy
  • NIS

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

In Vivo Imaging and Tumor Therapy with the Sodium Iodide Symporter. / Dingli, David M; Russell, Stephen J; Morris, John C.

In: Journal of Cellular Biochemistry, Vol. 90, No. 6, 15.12.2003, p. 1079-1086.

Research output: Contribution to journalArticle

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