Abstract
There has been great progress in the design of vectors for cancer gene therapy. However, it has been difficult to translate success in the laboratory into clinical practice. A major hurdle in understanding these failures has been the relative difficulty in monitoring repeatedly and non-invasively the biodistribution, gene expression and replication of these viral vector systems. With the advent of molecular imaging technology, this deficiency is being rapidly rectified. A number of reporter genes have been used to monitor gene expression. In this review, we discuss the role of the sodium iodide symporter (NIS) as a reporter and therapeutic gene for cancer gene therapy when combined with various radioactive isotopes.
Original language | English (US) |
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Pages (from-to) | 1079-1086 |
Number of pages | 8 |
Journal | Journal of cellular biochemistry |
Volume | 90 |
Issue number | 6 |
DOIs | |
State | Published - Dec 15 2003 |
Keywords
- Biodistribution
- Gene therapy
- NIS
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology