In vivo, high-frequency three-dimensional cardiac MR elastography: Feasibility in normal volunteers

Arvin Forghanian-Arani, Kevin L. Glaser, Shivaram P. Arunachalam, Phillip J. Rossman, David S. Lake, Joshua D Trazasko, Armando Manduca, Kiaran Patrick McGee, Richard Lorne Ehman, Philip A Araoz

Research output: Contribution to journalArticle

17 Scopus citations


Purpose: Noninvasive stiffness imaging techniques (elastography) can image myocardial tissue biomechanics in vivo. For cardiac MR elastography (MRE) techniques, the optimal vibration frequency for in vivo experiments is unknown. Furthermore, the accuracy of cardiac MRE has never been evaluated in a geometrically accurate phantom. Therefore, the purpose of this study was to determine the necessary driving frequency to obtain accurate three-dimensional (3D) cardiac MRE stiffness estimates in a geometrically accurate diastolic cardiac phantom and to determine the optimal vibration frequency that can be introduced in healthy volunteers. Methods: The 3D cardiac MRE was performed on eight healthy volunteers using 80Hz, 100Hz, 140Hz, 180Hz, and 220Hz vibration frequencies. These frequencies were tested in a geometrically accurate diastolic heart phantom and compared with dynamic mechanical analysis (DMA). Results: The 3D Cardiac MRE was shown to be feasible in volunteers at frequencies as high as 180Hz. MRE and DMA agreed within 5% at frequencies greater than 180Hz in the cardiac phantom. However, octahedral shear strain signal to noise ratios and myocardial coverage was shown to be highest at a frequency of 140Hz across all subjects. Conclusion: This study motivates future evaluation of high-frequency 3D MRE in patient populations.

Original languageEnglish (US)
JournalMagnetic Resonance in Medicine
StateAccepted/In press - 2016


  • Cardiac elastography
  • Cardiac MRE
  • Myocardial stiffness

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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