In vivo experimental intracranial aneurysm models: A systematic review

F. Bouzeghrane, O. Naggara, D. F. Kallmes, A. Berenstein, Jean Raymond

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations

Abstract

Animal models are necessary to develop and test innovations in aneurysm therapy before clinical introduction. This review aims at identifying the most likely candidates for standardizing preclinical testing of aneurysm devices. We systematically searched electronic databases for publications on animal aneurysm models from 1961-2008 to assess the methodologic quality of the studies and collect data on the patency and angiographic and pathologic outcomes of treatments. There has been a steady increase in the annual number of publications with time. Species that were most frequently used were dogs, rabbits, and rodents, followed by swine. Most publications are single-laboratory studies with variables and poorly validated outcome measures, a small number of subjects, and limited standardization of techniques. The most appropriate models to test for recurrences after endovascular occlusion were the surgical bifurcation model in dogs, and the elastase-induced aneurysm model in rabbits. A standardized multicenter study is needed to improve the preclinical evaluation of endovascular devices in aneurysm therapy.

Original languageEnglish (US)
Pages (from-to)418-423
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume31
Issue number3
DOIs
StatePublished - Mar 2010

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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