Abstract
Bone marrow-derived antigen-presenting cells (APCs) play a central role in the induction of tolerance to tumor antigens expressed by B-cell lymphomas. Here we show that in vivo disruption of this APC-mediated tolerogenic mechanism unveils an intrinsic ability of malignant B cells to efficiently present tumor antigens to antigen-specific CD4+ T cells, resulting in a strong antitumor effect. This intrinsic antigen-presenting ability of malignant B cells is, however, overridden by tolerogenic bone marrow-derived APCs, leading instead to T-cell unresponsiveness and lack of antitumor effect. These results highlight the concept that therapeutic strategies aimed at enhancing the antigen-presenting function of B-cell lymphomas might not succeed unless the tolerogenic mechanisms mediated by bone marrow-derived APCs are disrupted in the first place.
Original language | English (US) |
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Pages (from-to) | 2871-2878 |
Number of pages | 8 |
Journal | Blood |
Volume | 107 |
Issue number | 7 |
DOIs | |
State | Published - Apr 1 2006 |
ASJC Scopus subject areas
- Biochemistry
- Immunology
- Hematology
- Cell Biology